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    Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 13076, updated on 29-Aug-2017
    Official Symbol
    Cyp1a1provided by MGI
    Official Full Name
    cytochrome P450, family 1, subfamily a, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:88588
    See related
    Ensembl:ENSMUSG00000032315 Vega:OTTMUSG00000063205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AHH; AHRR; CP11; CYPIA1; P450-1
    Orthologs
    Location:
    9 B; 9 31.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (57687928..57703824)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (57535735..57551629)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene c-src tyrosine kinase Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene CDC-like kinase 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    demethylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    flavonoid 3'-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity, acting on diphenols and related substances as donors ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    vitamin D 24-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    9-cis-retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    amine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    coumarin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    dibenzo-p-dioxin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT dibenzo-p-dioxin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    flavonoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    heterocycle metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrogen peroxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insecticide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid hydroxylation ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    porphyrin-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    toxin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cytochrome P450 1A1
    Names
    cytochrome P450 subfamily I, polypeptide 1
    cytochrome P450, 1a1, aromatic compound inducible
    cytochrome P450-P1
    NP_001129531.1
    NP_034122.1
    XP_006510873.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136059.2NP_001129531.1  cytochrome P450 1A1

      See identical proteins and their annotated locations for NP_001129531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AW110759, Y00071
      Consensus CDS
      CCDS23230.1
      UniProtKB/Swiss-Prot
      P00184
      UniProtKB/TrEMBL
      Q05A20
      Related
      ENSMUSP00000034865.4, OTTMUSP00000079608, ENSMUST00000034865.5, OTTMUST00000153905
      Conserved Domains (1) summary
      pfam00067
      Location:44503
      p450; Cytochrome P450
    2. NM_009992.4NP_034122.1  cytochrome P450 1A1

      See identical proteins and their annotated locations for NP_034122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK005000, AW110759
      Consensus CDS
      CCDS23230.1
      UniProtKB/Swiss-Prot
      P00184
      UniProtKB/TrEMBL
      Q05A20
      Related
      ENSMUSP00000150277.1, OTTMUSP00000079607, ENSMUST00000216433.1, OTTMUST00000153904
      Conserved Domains (1) summary
      pfam00067
      Location:44503
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      57687928..57703824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510810.3XP_006510873.1  cytochrome P450 1A1 isoform X1

      See identical proteins and their annotated locations for XP_006510873.1

      UniProtKB/Swiss-Prot
      P00184
      UniProtKB/TrEMBL
      Q05A20
      Conserved Domains (1) summary
      pfam00067
      Location:44503
      p450; Cytochrome P450
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