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    Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A [ Mus musculus (house mouse) ]

    Gene ID: 17872, updated on 8-Oct-2017
    Official Symbol
    Ppp1r15aprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 15Aprovided by MGI
    Primary source
    MGI:MGI:1927072
    See related
    Ensembl:ENSMUSG00000040435 Vega:OTTMUSG00000024467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gadd34; Myd116; 9630030H21
    Orthologs
    Location:
    7; 7 B3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (45522917..45526268, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52778287..52781638, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene dihydrodiol dehydrogenase (dimeric) Neighboring gene tubby-like protein 2 Neighboring gene nucleobindin 1 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase I promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translational initiation by eIF2 alpha dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    protein phosphatase 1 regulatory subunit 15A
    Names
    growth arrest and DNA damage-inducible protein GADD34
    growth arrest and DNA-damage-inducible 34
    myeloid differentiation primary response gene 116
    myeloid differentiation primary response protein MyD116

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008654.2NP_032680.1  protein phosphatase 1 regulatory subunit 15A

      See identical proteins and their annotated locations for NP_032680.1

      Status: VALIDATED

      Source sequence(s)
      AC151602, AK079339, AW493042, BC138486
      Consensus CDS
      CCDS21249.1
      UniProtKB/Swiss-Prot
      P17564
      UniProtKB/TrEMBL
      B2RRL7
      Related
      ENSMUSP00000049488.8, OTTMUSP00000029250, ENSMUST00000042105.10, OTTMUST00000060014
      Conserved Domains (1) summary
      pfam10488
      Location:545612
      PP1c_bdg; Phosphatase-1 catalytic subunit binding region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      45522917..45526268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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