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    Gba glucosylceramidase beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684536, updated on 26-Sep-2017
    Official Symbol
    Gbaprovided by RGD
    Official Full Name
    glucosylceramidase betaprovided by RGD
    Primary source
    RGD:1589149
    See related
    Ensembl:ENSRNOG00000049281
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188511781..188522602)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (207931042..207937062)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 189, member B Neighboring gene uncharacterized LOC102550011 Neighboring gene Metaxin 1 Neighboring gene thrombospondin 3

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Markers

    Homology

    Clone Names

    • MGC188451

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    glucosylceramidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucosylceramidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucosylceramidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    beta-glucoside catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT cell death in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucosylceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glucosylceramide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein complex disassembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein lipidation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of water loss via skin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to dexamethasone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to testosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to thyroid hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sphingosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    sphingosine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    termination of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    termination of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal lumen ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glucosylceramidase
    Names
    glucocerebrosidase
    glucosidase, beta, acid
    NP_001121111.1
    XP_017446595.1
    XP_017446596.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127639.1NP_001121111.1  glucosylceramidase precursor

      See identical proteins and their annotated locations for NP_001121111.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166732
      UniProtKB/TrEMBL
      B2RYC9
      Related
      ENSRNOP00000063935.1, ENSRNOT00000074727.1
      Conserved Domains (1) summary
      cl23815
      Location:20512
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      188511781..188522602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591107.1XP_017446596.1  glucosylceramidase isoform X1

      UniProtKB/TrEMBL
      B2RYC9
      Conserved Domains (1) summary
      cl23815
      Location:20512
      Glyco_hydro_30; O-Glycosyl hydrolase family 30
    2. XM_017591106.1XP_017446595.1  glucosylceramidase isoform X1

      UniProtKB/TrEMBL
      B2RYC9
      Conserved Domains (1) summary
      cl23815
      Location:20512
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      168551737..168557757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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