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    Uchl1 ubiquitin C-terminal hydrolase L1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29545, updated on 8-Oct-2017
    Official Symbol
    Uchl1provided by RGD
    Official Full Name
    ubiquitin C-terminal hydrolase L1provided by RGD
    Primary source
    RGD:3928
    See related
    Ensembl:ENSRNOG00000002343
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    catalyzes the hydrolysis of ubiquitin carboxy-terminal thiolesters to form ubiquitin and a thiol; may play a role in neuropathic pain [RGD, Feb 2006]
    Orthologs
    Location:
    14p11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43133224..43143942, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (42928247..42938981, complement)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene paired-like homeobox 2b Neighboring gene LIM and calponin homology domains 1 Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene uncharacterized LOC108352746 Neighboring gene NOP2/Sun RNA methyltransferase family member 7

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    alpha-2A adrenergic receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-2A adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    omega peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    omega peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axon target recognition IEA
    Inferred from Electronic Annotation
    more info
     
    axon target recognition ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axonal transport of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    axonal transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuromuscular process IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection terminus IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L1
    Names
    PGP 9.5
    PGP9.5
    UCH-L1
    neuron cytoplasmic protein 9.5
    ubiquitin carboxy-terminal hydrolase L1
    ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
    ubiquitin thioesterase L1
    NP_058933.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017237.3NP_058933.2  ubiquitin carboxyl-terminal hydrolase isozyme L1

      See identical proteins and their annotated locations for NP_058933.2

      Status: PROVISIONAL

      Source sequence(s)
      BC060573
      UniProtKB/Swiss-Prot
      Q00981
      Related
      ENSRNOP00000003248.3, ENSRNOT00000003248.5
      Conserved Domains (1) summary
      cd09616
      Location:5219
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      43133224..43143942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      40639549..40650302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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