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    Pam peptidylglycine alpha-amidating monooxygenase [ Mus musculus (house mouse) ]

    Gene ID: 18484, updated on 25-May-2017
    Official Symbol
    Pamprovided by MGI
    Official Full Name
    peptidylglycine alpha-amidating monooxygenaseprovided by MGI
    Primary source
    MGI:MGI:97475
    See related
    Ensembl:ENSMUSG00000026335 Vega:OTTMUSG00000034777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PHM
    Orthologs
    Location:
    1 D; 1 47.76 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (97821091..98095658, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (99717671..99992209, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 1, ERATO Doi 622, expressed Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene predicted gene, 31771 Neighboring gene basic transcription factor 3 pseudogene Neighboring gene RIKEN cDNA B230216N24 gene Neighboring gene RIKEN cDNA 1810006J02 gene Neighboring gene predicted gene 29461

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    peptidylamidoglycolate lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidylglycine monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidylglycine monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peptide amidation ISO
    Inferred from Sequence Orthology
    more info
     
    peptide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptide metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    protein amidation ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    peptidyl-glycine alpha-amidating monooxygenase
    Names
    PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PRECURSOR (PAM)
    NP_038654.2
    XP_006529306.1
    XP_006529307.1
    XP_011246239.1
    XP_011246240.1
    XP_011246241.1
    XP_017174769.1
    XP_017174771.1
    XP_017174773.1
    XP_017174775.1
    XP_017174778.1
    XP_017174779.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013626.3NP_038654.2  peptidyl-glycine alpha-amidating monooxygenase precursor

      See identical proteins and their annotated locations for NP_038654.2

      Status: VALIDATED

      Source sequence(s)
      AK141291, BB662851, BC129869, U79523
      Consensus CDS
      CCDS48331.1
      UniProtKB/Swiss-Prot
      P97467
      UniProtKB/TrEMBL
      A1L331, F8VQA4
      Related
      ENSMUSP00000095228.3, ENSMUST00000097625.9
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      97821091..98095658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319289.1XP_017174778.1  peptidyl-glycine alpha-amidating monooxygenase isoform X7

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    2. XM_017319286.1XP_017174775.1  peptidyl-glycine alpha-amidating monooxygenase isoform X6

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    3. XM_011247938.2XP_011246240.1  peptidyl-glycine alpha-amidating monooxygenase isoform X5

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    4. XM_011247937.2XP_011246239.1  peptidyl-glycine alpha-amidating monooxygenase isoform X3

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    5. XM_017319284.1XP_017174773.1  peptidyl-glycine alpha-amidating monooxygenase isoform X4

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    6. XM_006529244.3XP_006529307.1  peptidyl-glycine alpha-amidating monooxygenase isoform X2

      See identical proteins and their annotated locations for XP_006529307.1

      UniProtKB/Swiss-Prot
      P97467
      Related
      ENSMUSP00000057112.8, OTTMUSP00000048159, ENSMUST00000058762.14, OTTMUST00000088381
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    7. XM_006529243.3XP_006529306.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    8. XM_017319290.1XP_017174779.1  peptidyl-glycine alpha-amidating monooxygenase isoform X9

      UniProtKB/TrEMBL
      E9Q704
      Related
      ENSMUSP00000125418.1, OTTMUSP00000048160, ENSMUST00000161567.7, OTTMUST00000088382
      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    9. XM_011247939.2XP_011246241.1  peptidyl-glycine alpha-amidating monooxygenase isoform X8

      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    10. XM_017319280.1XP_017174769.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    11. XM_017319282.1XP_017174771.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
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