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    C5 complement C5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362119, updated on 3-Apr-2017
    Official Symbol
    C5provided by RGD
    Official Full Name
    complement C5provided by RGD
    Primary source
    RGD:2237
    See related
    Ensembl:ENSRNOG00000018899 Vega:OTTRNOG00000002314
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hc; C5a; RGD1561905
    Summary
    likely component of the classical pathway of the complement cascade; may be involved with tissue injury associated with ischemia or sepsis; may be a component of the membrane attack complex [RGD, Feb 2006]
    Orthologs
    Location:
    3p11
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14206466..14229141, complement) , (14049993..14113931, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (19525468..19547636, complement) , (19369981..19432948, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550940 Neighboring gene TNF receptor-associated factor 1 Neighboring gene pre-B-cell leukemia transcription factor 3-like Neighboring gene 40S ribosomal protein S7-like Neighboring gene target of rapamycin complex 2 subunit MAPKAP1-like Neighboring gene uncharacterized LOC103691771 Neighboring gene similar to Complement C5 precursor

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    C5a anaphylatoxin chemotactic receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement activation IEA
    Inferred from Electronic Annotation
    more info
     
    complement activation, alternative pathway IEA
    Inferred from Electronic Annotation
    more info
     
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    leukocyte migration involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dopamine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of norepinephrine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    membrane attack complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    complement C5
    Names
    anaphylatoxin
    complement component 5

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      14049993..14113931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      14206466..14229141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761798.1XP_008760020.1  complement C5 isoform X1

      Related
      ENSRNOP00000076004.1, OTTRNOP00000002266, ENSRNOT00000092736.1, OTTRNOT00000003953
      Conserved Domains (7) summary
      cd00017
      Location:296364
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:609914
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      pfam00207
      Location:386473
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:10331123
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:665915
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:80220
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:11411290
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      12987748..13080508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001079130.6XP_001079130.2  complement C5 isoform X3

      Conserved Domains (8) summary
      cd00017
      Location:691759
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:10041309
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      pfam00207
      Location:781868
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:131224
      A2M_N; MG2 domain
      pfam07677
      Location:14281518
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10601310
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:475615
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:15361685
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
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