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    Snca synuclein, alpha [ Mus musculus (house mouse) ]

    Gene ID: 20617, updated on 26-Nov-2017
    Official Symbol
    Sncaprovided by MGI
    Official Full Name
    synuclein, alphaprovided by MGI
    Primary source
    MGI:MGI:1277151
    See related
    Ensembl:ENSMUSG00000025889 Vega:OTTMUSG00000057624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NACP; alphaSYN; alpha-Syn
    Expression
    Biased expression in liver E14 (RPKM 144.4), liver E14.5 (RPKM 119.8) and 10 other tissues See more
    Orthologs
    Location:
    6 B3; 6 29.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (60731573..60829855, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (60681567..60779849, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38823 Neighboring gene predicted gene, 35386 Neighboring gene melanoma antigen family B, 16, pseudogene 2 Neighboring gene multimerin 1 Neighboring gene protein phosphatase 6, catalytic subunit pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
      Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    arachidonic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cuprous ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    adult locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dopamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial ATP synthesis coupled electron transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dopamine uptake involved in synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    neutral lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of acyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of acyl-CoA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dopamine secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of dopamine secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    response to iron(II) ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
     
    synapse organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with platelet alpha granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    supramolecular fiber ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    alpha-synuclein
    Names
    non-A beta component of AD amyloid
    non-A4 component of amyloid

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042451.2NP_001035916.1  alpha-synuclein

      See identical proteins and their annotated locations for NP_001035916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC046764, BY782503
      Consensus CDS
      CCDS20201.1
      UniProtKB/Swiss-Prot
      O55042
      Related
      ENSMUSP00000109907.3, OTTMUSP00000073979, ENSMUST00000114268.4, OTTMUST00000141609
      Conserved Domains (1) summary
      pfam01387
      Location:1110
      Synuclein; Synuclein
    2. NM_009221.2NP_033247.1  alpha-synuclein

      See identical proteins and their annotated locations for NP_033247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF179273, BC046764
      Consensus CDS
      CCDS20201.1
      UniProtKB/Swiss-Prot
      O55042
      Related
      ENSMUSP00000126067.1, OTTMUSP00000073978, ENSMUST00000163779.7, OTTMUST00000141608
      Conserved Domains (1) summary
      pfam01387
      Location:1110
      Synuclein; Synuclein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      60731573..60829855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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