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    VPS35 VPS35, retromer complex component [ Homo sapiens (human) ]

    Gene ID: 55737, updated on 23-May-2018
    Official Symbol
    VPS35provided by HGNC
    Official Full Name
    VPS35, retromer complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:13487
    See related
    Ensembl:ENSG00000069329 MIM:601501; Vega:OTTHUMG00000132542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEM3; PARK17
    Summary
    This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in small intestine (RPKM 28.7), urinary bladder (RPKM 22.9) and 25 other tissues See more
    Orthologs
    See VPS35 in Genome Data Viewer
    Location:
    16q11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (46657979..46689232, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46693589..46723144, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SHC binding and spindle associated 1 Neighboring gene RAB43 pseudogene 1 Neighboring gene origin recognition complex subunit 6 Neighboring gene myosin light chain kinase 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The gp41 cytoplasmic tail binds directly to retromer components VPS26 and VPS35 in HIV-1-infected cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of vacuolar protein sorting 35 homolog (VPS35) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • WNT ligand biogenesis and trafficking, organism-specific biosystem (from REACTOME)
      WNT ligand biogenesis and trafficking, organism-specific biosystem19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the c...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ10752, FLJ13588, FLJ20388, DKFZp434E1211, DKFZp434P1672

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    D1 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial fragmentation involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of late endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lysosomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter receptor transport, endosome to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Wnt protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cellular protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of dopamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of locomotion involved in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to organelle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular protein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of presynapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, endosome to Golgi NAS
    Non-traceable Author Statement
    more info
    PubMed 
    retrograde transport, endosome to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voluntary musculoskeletal movement IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosomal membrane HDA PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion-derived vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retromer complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retromer complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    retromer complex TAS
    Traceable Author Statement
    more info
    PubMed 
    retromer, cargo-selective complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retromer, cargo-selective complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    tubular endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vacuolar protein sorting-associated protein 35
    Names
    hVPS35
    maternal-embryonic 3
    vacuolar protein sorting 35 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029970.1 RefSeqGene

      Range
      5001..36254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018206.5NP_060676.2  vacuolar protein sorting-associated protein 35

      See identical proteins and their annotated locations for NP_060676.2

      Status: REVIEWED

      Source sequence(s)
      AC012186, BC093036, BQ574179, BU621624, DB049686
      Consensus CDS
      CCDS10721.1
      UniProtKB/Swiss-Prot
      Q96QK1
      Related
      ENSP00000299138.7, OTTHUMP00000163364, ENST00000299138.11, OTTHUMT00000255742
      Conserved Domains (1) summary
      pfam03635
      Location:15752
      Vps35; Vacuolar protein sorting-associated protein 35

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      46657979..46689232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256045.3XP_005256102.1  vacuolar protein sorting-associated protein 35 isoform X2

      See identical proteins and their annotated locations for XP_005256102.1

      Conserved Domains (1) summary
      pfam03635
      Location:1685
      Vps35; Vacuolar protein sorting-associated protein 35
    2. XM_011523227.3XP_011521529.1  vacuolar protein sorting-associated protein 35 isoform X1

      See identical proteins and their annotated locations for XP_011521529.1

      Conserved Domains (1) summary
      pfam03635
      Location:1723
      Vps35; Vacuolar protein sorting-associated protein 35
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