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    STAT3 signal transducer and activator of transcription 3 [ Homo sapiens (human) ]

    Gene ID: 6774, updated on 8-Nov-2017
    Official Symbol
    STAT3provided by HGNC
    Official Full Name
    signal transducer and activator of transcription 3provided by HGNC
    Primary source
    HGNC:HGNC:11364
    See related
    Ensembl:ENSG00000168610 MIM:102582; Vega:OTTHUMG00000150645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APRF; HIES; ADMIO; ADMIO1
    Summary
    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    17q21.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (42313324..42388505, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40465342..40540586, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 5B Neighboring gene uncharacterized LOC107984978 Neighboring gene signal transducer and activator of transcription 5A Neighboring gene caveolae associated protein 1 Neighboring gene uncharacterized LOC102725238 Neighboring gene RNA, U7 small nuclear 97 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Autoimmune disease, multisystem, infantile-onset, 1
    MedGen: C4014795 OMIM: 615952 GeneReviews: Not available
    Compare labs
    Hyperimmunoglobulin E syndrome Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
    NHGRI GWA Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    NHGRI GWA Catalog
    Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155) PubMed
    env HIV-1 gp120-induced release of IL-6 activates STAT3 in primary human monocyte-derived dendritic cells PubMed
    env HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells PubMed
    env HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
    env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    Nef nef HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
    nef Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation of STAT3 PubMed
    nef HIV-1 Nef induces phosphorylation of STAT3 in M2-type macrophages PubMed
    nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
    nef HIV-1 Nef activates signal transducer and activator of transcription 3 (STAT3) in the granulocyte-macrophage colony-stimulating factor-independent myeloid cell line, TF-1, and in primary human macrophages PubMed
    nef HIV-1 Nef specifically activates STAT3 in primary human monocyte-derived macrophages (MDM); Nef-dependent STAT3 activation is mediated by the release of soluble factor(s), including MIP-1alpha and IL-6 PubMed
    nef HIV-1 Nef activates expression of phospho-Stat3, one of the downstream signaling pathways for cell proliferation PubMed
    nef HIV-1 Nef, through its PxxP and RR106 motifs, upregulates Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation, and activates the Ras-c-Raf-MAPK1,2 pathway in podocytes PubMed
    nef The expression of HIV-1 Nef in immature dendritic cells activates STAT3 PubMed
    Tat tat HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in GFAP, Egr-1 and p300 transcription and protein expression in both Tat-expressing astrocytes and HIV-infected astrocytes PubMed
    tat Expression of HIV-1 Tat upregulates the abundance of signal transducer and activator of transcription 3 (STAT3) in the nucleoli of Jurkat T-cells PubMed
    tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
    tat IL10 and STAT3 are required for HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells PubMed
    tat Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication PubMed
    matrix gag HIV-1 MA recruits STAT3 to the LXR promoter region containing the STAT responsive sequence TTCAGGGAA; STAT3 mediates upregulation of NR1H3 (LXR-alpha) gene expression PubMed
    gag HIV-1 MA increases phosphorylation of STAT3 PubMed
    gag HIV-1 MA natural variant S75X upregulates the expression of STAT1 and STAT3, and induces phosphorylation of STAT1 at position S727 and STAT3 at position Y705 in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed
    gag HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways PubMed
    gag Treatment of human stellate cells with HIV-1 MA induces phosphorylation of STAT1 and STAT3 proteins PubMed

    Go to the HIV-1, Human Interaction Database

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      Neurotrophic factor-mediated Trk receptor signaling
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch pathway is an evolutionally conserved signaling pathway which plays an important role in diverse developmental and physiological processes. These include cell-fate determination, tissue pat...
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
    • PDGF Pathway, organism-specific biosystem (from WikiPathways)
      PDGF Pathway, organism-specific biosystemPDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; H...
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation, organism-specific biosystem (from REACTOME)
      POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation, organism-specific biosystemPOU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of target genes. The target genes of each transcription factor overlap extensively: POU5F1, SOX2, and NANOG co-occupy at least 353 genes ...
    • PTK6 Activates STAT3, organism-specific biosystem (from REACTOME)
      PTK6 Activates STAT3, organism-specific biosystemPTK6-mediated phosphorylation activates STAT3 transcription factor via STAP2 adapter protein. STAT3 transcriptional target SOCS3 is a negative regulator of PTK6 and inhibits PTK6-mediated phosphoryla...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystem (from WikiPathways)
      Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystemPathways in physiological and pathological hypertrophy of the heart. Largely based on the article from Wang Y; ''Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathologica...
    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
    • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
      Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolactin signaling pathway, conserved biosystem (from KEGG)
      Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Protein folding, organism-specific biosystem (from REACTOME)
      Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RAC1 signaling pathway, organism-specific biosystem
      RAC1 signaling pathway
    • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
      Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
    • Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
      Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystemThe culture medium of senescent cells in enriched in secreted proteins when compared with the culture medium of quiescent i.e. presenescent cells and these secreted proteins constitute the so-called ...
    • Serotonin Receptor 2 and STAT3 Signaling, organism-specific biosystem (from WikiPathways)
      Serotonin Receptor 2 and STAT3 Signaling, organism-specific biosystemSource: Ariadne Genomics Pathway Studio.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
    • Signaling by FGFR1 in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1 in disease, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by MET, organism-specific biosystem (from REACTOME)
      Signaling by MET, organism-specific biosystemMET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by PTK6, organism-specific biosystem (from REACTOME)
      Signaling by PTK6, organism-specific biosystemPTK6 (BRK) is an oncogenic non-receptor tyrosine kinase that functions downstream of ERBB2 (HER2) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et ...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by cytosolic FGFR1 fusion mutants, organism-specific biosystem (from REACTOME)
      Signaling by cytosolic FGFR1 fusion mutants, organism-specific biosystem8p11 myeloproliferative syndrome (EMS) is an aggressive disorder that is associated with a translocation event at the FGFR1 gene on chromosome 8p11. Typical symptoms upon diagnosis include eosinophi...
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to STAT3, organism-specific biosystem (from REACTOME)
      Signalling to STAT3, organism-specific biosystemNeurotrophin-induced increase in Signal transducer and activator of transcription 3 (STAT3; acute-phase response factor) activation appears to underly several downstream functions of neurotrophin sig...
    • TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer, organism-specific biosystem (from WikiPathways)
      TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer, organism-specific biosystemSchematic showing the shift in nutrient utilization in TCA cycle with increasing degree of invasiveness. Low-invasive ovarian cancer (OVCA) cells are glucose dependent for their TCA cycle pool. With ...
    • TFs Regulate miRNAs related to cardiac hypertrophy, organism-specific biosystem (from WikiPathways)
      TFs Regulate miRNAs related to cardiac hypertrophy, organism-specific biosystemTranscription Factors that possibly regulate the expression of microRNAs related to cardiac hypertrophy. Interactions found by using TransMir. MicroRNAs are represented by a purple color and a rounde...
    • TGF-beta Receptor Signaling, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
      Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem
      Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Transcriptional regulation of pluripotent stem cells, organism-specific biosystem (from REACTOME)
      Transcriptional regulation of pluripotent stem cells, organism-specific biosystemPluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, P...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20882, MGC16063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CCR5 chemokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    JAK-STAT cascade involved in growth hormone signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    JAK-STAT cascade involved in growth hormone signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-helper 17 cell lineage commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to leptin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    eating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    eye photoreceptor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interleukin-12-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    interleukin-15-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    interleukin-6-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-6-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-7-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    intracellular receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leptin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA mediated inhibition of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrogen peroxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of metalloendopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of pri-miRNA transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein TAS
    Traceable Author Statement
    more info
     
    positive regulation of vascular endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    radial glial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of mitochondrial membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to leptin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sexual reproduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    somatic stem cell population maintenance TAS
    Traceable Author Statement
    more info
     
    temperature homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IC
    Inferred by Curator
    more info
    PubMed 
    RNA polymerase II transcription factor complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    signal transducer and activator of transcription 3
    Names
    DNA-binding protein APRF
    acute-phase response factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007370.1 RefSeqGene

      Range
      5001..80171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_112

    mRNA and Protein(s)

    1. NM_003150.3NP_003141.2  signal transducer and activator of transcription 3 isoform 2

      See identical proteins and their annotated locations for NP_003141.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI631896, AK092965, BC000627, BC008044, BI461226, CB216860, CF454565
      Consensus CDS
      CCDS32657.1
      UniProtKB/Swiss-Prot
      P40763
      Related
      ENSP00000384943.3, OTTHUMP00000198128, ENST00000404395.3, OTTHUMT00000319365
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    2. NM_139276.2NP_644805.1  signal transducer and activator of transcription 3 isoform 1

      See identical proteins and their annotated locations for NP_644805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).
      Source sequence(s)
      AI631896, AK092965, BC008044, BC014482, BI461226, CB216860, CF454565
      Consensus CDS
      CCDS32656.1
      UniProtKB/Swiss-Prot
      P40763
      Related
      ENSP00000264657.4, OTTHUMP00000198123, ENST00000264657.9, OTTHUMT00000319353
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    3. NM_213662.1NP_998827.1  signal transducer and activator of transcription 3 isoform 3

      See identical proteins and their annotated locations for NP_998827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also called STAT3B or STAT3beta, uses an alternate splice site in the 3' coding region, resulting in an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI631896, AK092965, BC008044, BC014482, CB216860, CB321646, CF454565
      Consensus CDS
      CCDS59288.1
      UniProtKB/Swiss-Prot
      P40763
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      42313324..42388505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024973.1XP_016880462.1  signal transducer and activator of transcription 3 isoform X4

      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    2. XM_011525146.2XP_011523448.1  signal transducer and activator of transcription 3 isoform X3

      See identical proteins and their annotated locations for XP_011523448.1

      UniProtKB/Swiss-Prot
      P40763
      Related
      ENSP00000467000.1, OTTHUMP00000263433, ENST00000585517.5, OTTHUMT00000449929
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    3. XM_011525145.2XP_011523447.1  signal transducer and activator of transcription 3 isoform X1

      See identical proteins and their annotated locations for XP_011523447.1

      UniProtKB/Swiss-Prot
      P40763
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    4. XM_005257616.3XP_005257673.2  signal transducer and activator of transcription 3 isoform X2

      See identical proteins and their annotated locations for XP_005257673.2

      UniProtKB/Swiss-Prot
      P40763
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    5. XM_017024972.1XP_016880461.1  signal transducer and activator of transcription 3 isoform X3

      UniProtKB/Swiss-Prot
      P40763
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    6. XM_005257617.3XP_005257674.2  signal transducer and activator of transcription 3 isoform X1

      See identical proteins and their annotated locations for XP_005257674.2

      UniProtKB/Swiss-Prot
      P40763
      Related
      ENSP00000467985.1, OTTHUMP00000263435, ENST00000588969.5, OTTHUMT00000449932
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    7. XM_017024975.1XP_016880464.1  signal transducer and activator of transcription 3 isoform X2

      UniProtKB/Swiss-Prot
      P40763
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    8. XM_017024974.1XP_016880463.1  signal transducer and activator of transcription 3 isoform X4

      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain
    9. XM_017024976.1XP_016880465.1  signal transducer and activator of transcription 3 isoform X4

      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:141319
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:321573
      STAT_bind; STAT protein, DNA binding domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      40701045..40776137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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