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    SUCLA2 succinate-CoA ligase ADP-forming beta subunit [ Homo sapiens (human) ]

    Gene ID: 8803, updated on 8-May-2017
    Official Symbol
    SUCLA2provided by HGNC
    Official Full Name
    succinate-CoA ligase ADP-forming beta subunitprovided by HGNC
    Primary source
    HGNC:HGNC:11448
    See related
    Ensembl:ENSG00000136143 MIM:603921; Vega:OTTHUMG00000016889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A-SCS; A-BETA; MTDPS5; SCS-betaA
    Summary
    Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    13q14.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (47942656..48037972, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48516791..48612125, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27a pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 444 Neighboring gene long intergenic non-protein coding RNA 562 Neighboring gene nudix hydrolase 15 Neighboring gene MED4 antisense RNA 1 Neighboring gene uncharacterized LOC105370198 Neighboring gene mediator complex subunit 4 Neighboring gene RNA polymerase II subunit K pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of aging.
    NHGRI GWA Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog
    Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    succinate-CoA ligase (ADP-forming) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    succinate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    succinyl-CoA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    succinyl-CoA pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
    Names
    ATP-specific succinyl-CoA synthetase subunit beta
    ATP-specific succinyl-CoA synthetase, beta subunit
    mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta
    renal carcinoma antigen NY-REN-39
    succinate--CoA ligase (ADP-forming)
    succinate-CoA ligase beta subunit
    succinyl-CoA synthetase beta-A chain
    NP_003841.1
    XP_016876295.1
    XP_016876296.1
    XP_016876297.1
    XP_016876298.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008241.1 RefSeqGene

      Range
      5001..63672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003850.2NP_003841.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_003841.1

      Status: REVIEWED

      Source sequence(s)
      AB035863, AL080096
      Consensus CDS
      CCDS9406.1
      UniProtKB/Swiss-Prot
      Q9P2R7
      UniProtKB/TrEMBL
      E5KS60, Q9Y4T0
      Related
      ENSP00000367923.3, OTTHUMP00000018384, ENST00000378654.8, OTTHUMT00000044852
      Conserved Domains (3) summary
      PRK00696
      Location:55445
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:321441
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:55262
      ATP-grasp_2; ATP-grasp domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      47942656..48037972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020806.1XP_016876295.1  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1

    2. XM_017020809.1XP_016876298.1  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X4

      Conserved Domains (2) summary
      pfam00549
      Location:187307
      Ligase_CoA; CoA-ligase
      cl17255
      Location:1128
      ATP-grasp_4; ATP-grasp domain
    3. XM_017020807.1XP_016876296.1  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X2

      Conserved Domains (3) summary
      PRK00696
      Location:12366
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:242362
      Ligase_CoA; CoA-ligase
      cl17255
      Location:12183
      ATP-grasp_4; ATP-grasp domain
    4. XM_017020808.1XP_016876297.1  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X3

    RNA

    1. XR_001749704.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      48484523..48543193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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