Format

Send to:

Choose Destination

Links from Books

    • Showing Current items.

    CNBP CCHC-type zinc finger nucleic acid binding protein [ Homo sapiens (human) ]

    Gene ID: 7555, updated on 9-Jul-2017
    Official Symbol
    CNBPprovided by HGNC
    Official Full Name
    CCHC-type zinc finger nucleic acid binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13164
    See related
    Ensembl:ENSG00000169714 MIM:116955; Vega:OTTHUMG00000159943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DM2; ZNF9; CNBP1; PROMM; RNF163; ZCCHC22
    Summary
    This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
    Orthologs
    Location:
    3q21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (129167815..129183967, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128886658..128902810, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ISY1-RAB43 readthrough Neighboring gene RAB43, member RAS oncogene family Neighboring gene ISY1 splicing factor homolog Neighboring gene uncharacterized LOC105374101 Neighboring gene ribosomal protein S27 pseudogene 12

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ11631

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cholesterol biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    cellular nucleic acid-binding protein
    Names
    erythroid differentiation-related
    sterol regulatory element-binding protein
    zinc finger protein 273
    zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011902.1 RefSeqGene

      Range
      5001..21153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127192.1NP_001120664.1  cellular nucleic acid-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001120664.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC108673, AK292119, BU616793, DB027227
      Consensus CDS
      CCDS46906.1
      UniProtKB/Swiss-Prot
      P62633
      Related
      ENSP00000410769.2, OTTHUMP00000233225, ENST00000441626.6, OTTHUMT00000390200
      Conserved Domains (1) summary
      PTZ00368
      Location:54173
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    2. NM_001127193.1NP_001120665.1  cellular nucleic acid-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001120665.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant, also known as alpha variant 1, uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AC108673, BU616793, DB027227, DQ091187
      Consensus CDS
      CCDS46907.1
      UniProtKB/Swiss-Prot
      P62633
      Related
      ENSP00000399488.2, OTTHUMP00000233223, ENST00000451728.6, OTTHUMT00000390198
      Conserved Domains (1) summary
      PTZ00368
      Location:54172
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    3. NM_001127194.1NP_001120666.1  cellular nucleic acid-binding protein isoform 4

      See identical proteins and their annotated locations for NP_001120666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant, also known as beta variant 2, uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 4).
      Source sequence(s)
      AC108673, BU616793, DA606481, DB027227, DQ092367
      Consensus CDS
      CCDS46908.1
      UniProtKB/Swiss-Prot
      P62633
      Related
      ENSP00000400444.2, OTTHUMP00000233224, ENST00000446936.6, OTTHUMT00000390199
      Conserved Domains (1) summary
      PTZ00368
      Location:47166
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    4. NM_001127195.1NP_001120667.1  cellular nucleic acid-binding protein isoform 5

      See identical proteins and their annotated locations for NP_001120667.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant, also known as beta variant 1, uses two alternate in-frame splice sites in the 5' and central coding regions, compared to variant 1, resulting in a shorter protein (isoform 5).
      Source sequence(s)
      AC108673, BU616793, DB027227, DQ092366
      UniProtKB/Swiss-Prot
      P62633
      Conserved Domains (1) summary
      PTZ00368
      Location:47165
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    5. NM_001127196.1NP_001120668.1  cellular nucleic acid-binding protein isoform 6

      See identical proteins and their annotated locations for NP_001120668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant uses two alternate in-frame splice sites in the 5' and central coding regions, compared to variant 1, resulting in a shorter protein (isoform 6).
      Source sequence(s)
      AC108673, BC014911, BU616793, DB027227
      Consensus CDS
      CCDS54637.1
      UniProtKB/Swiss-Prot
      P62633
      UniProtKB/TrEMBL
      A0A0S2Z4Q3
      Related
      ENSP00000421323.1, OTTHUMP00000217106, ENST00000502976.5, OTTHUMT00000358420
      Conserved Domains (1) summary
      PTZ00368
      Location:47164
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    6. NM_003418.4NP_003409.1  cellular nucleic acid-binding protein isoform 3

      See identical proteins and their annotated locations for NP_003409.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 3).
      Source sequence(s)
      AC108673, BC093058, BU616793, DB027227
      Consensus CDS
      CCDS3056.1
      UniProtKB/Swiss-Prot
      P62633
      UniProtKB/TrEMBL
      A0A0S2Z4K2
      Related
      ENSP00000410619.2, OTTHUMP00000217105, ENST00000422453.6, OTTHUMT00000358419
      Conserved Domains (1) summary
      PTZ00368
      Location:54171
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      129167815..129183967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      128850015..128866149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center