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    P2RY2 purinergic receptor P2Y2 [ Homo sapiens (human) ]

    Gene ID: 5029, updated on 23-Nov-2021

    Summary

    Official Symbol
    P2RY2provided by HGNC
    Official Full Name
    purinergic receptor P2Y2provided by HGNC
    Primary source
    HGNC:HGNC:8541
    See related
    Ensembl:ENSG00000175591 MIM:600041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
    Summary
    The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See P2RY2 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73218281..73242427)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72929326..72953472)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369381 Neighboring gene Sharpr-MPRA regulatory region 14106 Neighboring gene Sharpr-MPRA regulatory region 2548 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
    GeneReviews: Not available
    Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ37408, MGC20088, MGC40010, DKFZp686H09192

    General protein information

    Preferred Names
    P2Y purinoceptor 2
    Names
    ATP receptor
    P2U nucleotide receptor
    P2U purinoceptor 1
    P2U receptor 1
    purinergic receptor P2Y, G-protein coupled, 2
    purinoceptor P2Y2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002564.4NP_002555.4  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      Related
      ENSP00000377222.2, ENST00000393597.7
      Conserved Domains (1) summary
      cd15373
      Location:34317
      7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_176071.3NP_788085.3  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      Related
      ENSP00000377221.2, ENST00000393596.2
      Conserved Domains (1) summary
      cd15373
      Location:34317
      7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_176072.3NP_788086.3  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      Related
      ENSP00000310305.2, ENST00000311131.6
      Conserved Domains (1) summary
      cd15373
      Location:34317
      7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      73218281..73242427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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