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    ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Homo sapiens (human) ]

    Gene ID: 9826, updated on 18-Aug-2020

    Summary

    Official Symbol
    ARHGEF11provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 11provided by HGNC
    Primary source
    HGNC:HGNC:14580
    See related
    Ensembl:ENSG00000132694 MIM:605708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GTRAP48; PDZ-RHOGEF
    Summary
    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 7.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See ARHGEF11 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156934840..157046903, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156904632..157015512, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor related receptor Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene leucine rich repeat containing 71 Neighboring gene microRNA 765 Neighboring gene RNA, 7SL, cytoplasmic 612, pseudogene Neighboring gene uncharacterized LOC102724222 Neighboring gene SMU1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0380, DKFZp667F1223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Rho guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 11
    Names
    Rho guanine exchange factor (GEF) 11
    Rho guanine nucleotide exchange factor (GEF) 11
    RhoA-specific guanine nucleotide exchange factor
    RhoGEF glutamate transport modulator
    glutamate transporter EAAT4-associated protein 48

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377418.1NP_001364347.1  rho guanine nucleotide exchange factor 11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL157713, AL356104
    2. NM_001377419.1NP_001364348.1  rho guanine nucleotide exchange factor 11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL157713, AL356104
    3. NM_014784.4NP_055599.1  rho guanine nucleotide exchange factor 11 isoform 1

      See identical proteins and their annotated locations for NP_055599.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AB002378, AL157713, BC057394
      Consensus CDS
      CCDS1162.1
      UniProtKB/Swiss-Prot
      O15085
      Related
      ENSP00000354644.2, ENST00000361409.2
      Conserved Domains (6) summary
      cd08753
      Location:290434
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61139
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9391081
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:9991079
      PH; PH domain
      pfam00621
      Location:738922
      RhoGEF; RhoGEF domain
    4. NM_198236.3NP_937879.1  rho guanine nucleotide exchange factor 11 isoform 2

      See identical proteins and their annotated locations for NP_937879.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.
      Source sequence(s)
      AL157713, BC057394
      Consensus CDS
      CCDS1163.1
      UniProtKB/Swiss-Prot
      O15085
      Related
      ENSP00000357177.3, ENST00000368194.7
      Conserved Domains (6) summary
      cd08753
      Location:330474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61139
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9791121
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10391119
      PH; PH domain
      pfam00621
      Location:778962
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      156934840..157046903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002923.2XP_016858412.1  rho guanine nucleotide exchange factor 11 isoform X13

    2. XM_005245629.5XP_005245686.1  rho guanine nucleotide exchange factor 11 isoform X7

      Conserved Domains (6) summary
      cd08753
      Location:330474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61139
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9801122
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10401120
      PH; PH domain
      pfam00621
      Location:779963
      RhoGEF; RhoGEF domain
    3. XM_017002920.2XP_016858409.1  rho guanine nucleotide exchange factor 11 isoform X5

    4. XM_017002924.2XP_016858413.1  rho guanine nucleotide exchange factor 11 isoform X14

    5. XM_011510185.3XP_011508487.1  rho guanine nucleotide exchange factor 11 isoform X3

      Conserved Domains (6) summary
      cd08753
      Location:341485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:72150
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:57131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9911133
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10511131
      PH; PH domain
      pfam00621
      Location:790974
      RhoGEF; RhoGEF domain
    6. XM_017002922.2XP_016858411.1  rho guanine nucleotide exchange factor 11 isoform X12

    7. XM_006711665.4XP_006711728.1  rho guanine nucleotide exchange factor 11 isoform X11

      Conserved Domains (6) summary
      cd08753
      Location:306450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9551097
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10151095
      PH; PH domain
      pfam00621
      Location:754938
      RhoGEF; RhoGEF domain
    8. XM_011510186.3XP_011508488.1  rho guanine nucleotide exchange factor 11 isoform X10

      Conserved Domains (6) summary
      cd08753
      Location:306450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9561098
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10161096
      PH; PH domain
      pfam00621
      Location:755939
      RhoGEF; RhoGEF domain
    9. XM_006711662.3XP_006711725.1  rho guanine nucleotide exchange factor 11 isoform X6

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9851127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10451125
      PH; PH domain
      pfam00621
      Location:784968
      RhoGEF; RhoGEF domain
    10. XM_006711660.4XP_006711723.1  rho guanine nucleotide exchange factor 11 isoform X2

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9951137
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10551135
      PH; PH domain
      pfam00621
      Location:794978
      RhoGEF; RhoGEF domain
    11. XM_006711661.3XP_006711724.1  rho guanine nucleotide exchange factor 11 isoform X4

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9861128
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10461126
      PH; PH domain
      pfam00621
      Location:785969
      RhoGEF; RhoGEF domain
    12. XM_006711659.3XP_006711722.1  rho guanine nucleotide exchange factor 11 isoform X1

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9961138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10561136
      PH; PH domain
      pfam00621
      Location:795979
      RhoGEF; RhoGEF domain
    13. XM_011510187.3XP_011508489.1  rho guanine nucleotide exchange factor 11 isoform X15

      Conserved Domains (5) summary
      cd08753
      Location:252396
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00228
      Location:242
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd13391
      Location:9021044
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:9621042
      PH; PH domain
      pfam00621
      Location:701885
      RhoGEF; RhoGEF domain
    14. XM_005245633.4XP_005245690.1  rho guanine nucleotide exchange factor 11 isoform X16

      Conserved Domains (4) summary
      cd13391
      Location:558700
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:618698
      PH; PH domain
      pfam00621
      Location:357541
      RhoGEF; RhoGEF domain
      cl02565
      Location:2105
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    15. XM_011510189.3XP_011508491.1  rho guanine nucleotide exchange factor 11 isoform X17

      Conserved Domains (3) summary
      cd13391
      Location:362504
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:422502
      PH; PH domain
      pfam00621
      Location:161345
      RhoGEF; RhoGEF domain
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