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    MTRF1 mitochondrial translation release factor 1 [ Homo sapiens (human) ]

    Gene ID: 9617, updated on 12-May-2019

    Summary

    Official Symbol
    MTRF1provided by HGNC
    Official Full Name
    mitochondrial translation release factor 1provided by HGNC
    Primary source
    HGNC:HGNC:7469
    See related
    Ensembl:ENSG00000120662 MIM:604601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RF1; MRF1; MTTRF1
    Summary
    The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 2.7), lymph node (RPKM 2.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See MTRF1 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (41216369..41312038, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41790505..41837731, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929140 Neighboring gene mortality factor 4 like 1 pseudogene 4 Neighboring gene kelch repeat and BTB domain containing 7 Neighboring gene uncharacterized LOC105370173 Neighboring gene Rac family small GTPase 1 pseudogene 3 Neighboring gene N(alpha)-acetyltransferase 16, NatA auxiliary subunit Neighboring gene RNA, U6 small nuclear 57, pseudogene Neighboring gene tubulin beta pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC47721

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation release factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    translation release factor activity, codon specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of translational termination TAS
    Traceable Author Statement
    more info
    PubMed 
    translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    peptide chain release factor 1, mitochondrial
    Names
    MRF-1
    mitochondrial translational release factor 1
    mitochontrial peptide chain release factor 1
    mtRF-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354073.1NP_001341002.1  peptide chain release factor 1, mitochondrial

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AL354696
      Consensus CDS
      CCDS9378.1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    2. NM_001354074.1NP_001341003.1  peptide chain release factor 1, mitochondrial

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AL354696
      Consensus CDS
      CCDS9378.1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    3. NM_001354076.1NP_001341005.1  peptide chain release factor 1, mitochondrial

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AL354696
      Consensus CDS
      CCDS9378.1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    4. NM_004294.4NP_004285.2  peptide chain release factor 1, mitochondrial

      See identical proteins and their annotated locations for NP_004285.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AL354696
      Consensus CDS
      CCDS9378.1
      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Related
      ENSP00000368793.3, ENST00000379480.9
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      41216369..41312038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020856.1XP_016876345.1  peptide chain release factor 1, mitochondrial isoform X1

      Conserved Domains (3) summary
      PRK00591
      Location:131488
      prfA; peptide chain release factor 1; Validated
      pfam00472
      Location:344449
      RF-1; RF-1 domain
      pfam03462
      Location:151334
      PCRF; PCRF domain
    2. XM_017020860.1XP_016876349.1  peptide chain release factor 1, mitochondrial isoform X3

      Conserved Domains (3) summary
      PRK00591
      Location:92449
      prfA; peptide chain release factor 1; Validated
      pfam00472
      Location:305410
      RF-1; RF-1 domain
      pfam03462
      Location:112295
      PCRF; PCRF domain
    3. XM_017020857.1XP_016876346.1  peptide chain release factor 1, mitochondrial isoform X1

      Conserved Domains (3) summary
      PRK00591
      Location:131488
      prfA; peptide chain release factor 1; Validated
      pfam00472
      Location:344449
      RF-1; RF-1 domain
      pfam03462
      Location:151334
      PCRF; PCRF domain
    4. XM_011535321.2XP_011533623.1  peptide chain release factor 1, mitochondrial isoform X5

      See identical proteins and their annotated locations for XP_011533623.1

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    5. XM_017020875.1XP_016876364.1  peptide chain release factor 1, mitochondrial isoform X5

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    6. XM_024449443.1XP_024305211.1  peptide chain release factor 1, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    7. XM_017020858.1XP_016876347.1  peptide chain release factor 1, mitochondrial isoform X1

      Conserved Domains (3) summary
      PRK00591
      Location:131488
      prfA; peptide chain release factor 1; Validated
      pfam00472
      Location:344449
      RF-1; RF-1 domain
      pfam03462
      Location:151334
      PCRF; PCRF domain
    8. XM_011535317.2XP_011533619.1  peptide chain release factor 1, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_011533619.1

      Conserved Domains (3) summary
      PRK00591
      Location:92449
      prfA; peptide chain release factor 1; Validated
      pfam00472
      Location:305410
      RF-1; RF-1 domain
      pfam03462
      Location:112295
      PCRF; PCRF domain
    9. XM_011535315.2XP_011533617.1  peptide chain release factor 1, mitochondrial isoform X1

      Conserved Domains (3) summary
      PRK00591
      Location:131488
      prfA; peptide chain release factor 1; Validated
      pfam00472
      Location:344449
      RF-1; RF-1 domain
      pfam03462
      Location:151334
      PCRF; PCRF domain
    10. XM_024449440.1XP_024305208.1  peptide chain release factor 1, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    11. XM_017020869.2XP_016876358.1  peptide chain release factor 1, mitochondrial isoform X5

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    12. XM_006719900.2XP_006719963.1  peptide chain release factor 1, mitochondrial isoform X5

      See identical proteins and their annotated locations for XP_006719963.1

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    13. XM_017020866.2XP_016876355.1  peptide chain release factor 1, mitochondrial isoform X5

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    14. XM_017020865.2XP_016876354.1  peptide chain release factor 1, mitochondrial isoform X5

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    15. XM_017020874.1XP_016876363.1  peptide chain release factor 1, mitochondrial isoform X5

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    16. XM_011535323.2XP_011533625.1  peptide chain release factor 1, mitochondrial isoform X5

      See identical proteins and their annotated locations for XP_011533625.1

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    17. XM_017020877.1XP_016876366.1  peptide chain release factor 1, mitochondrial isoform X10

    18. XM_011535318.3XP_011533620.1  peptide chain release factor 1, mitochondrial isoform X5

      See identical proteins and their annotated locations for XP_011533620.1

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    19. XM_011535320.2XP_011533622.1  peptide chain release factor 1, mitochondrial isoform X5

      See identical proteins and their annotated locations for XP_011533622.1

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Related
      ENSP00000368790.1, ENST00000379477.5
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    20. XM_011535325.2XP_011533627.1  peptide chain release factor 1, mitochondrial isoform X5

      See identical proteins and their annotated locations for XP_011533627.1

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    21. XM_017020868.1XP_016876357.1  peptide chain release factor 1, mitochondrial isoform X5

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    22. XM_006719898.2XP_006719961.1  peptide chain release factor 1, mitochondrial isoform X5

      See identical proteins and their annotated locations for XP_006719961.1

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    23. XM_017020867.1XP_016876356.1  peptide chain release factor 1, mitochondrial isoform X5

      UniProtKB/Swiss-Prot
      O75570
      UniProtKB/TrEMBL
      A0A024RDT1
      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    24. XM_024449442.1XP_024305210.1  peptide chain release factor 1, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    25. XM_024449441.1XP_024305209.1  peptide chain release factor 1, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl27687
      Location:79436
      RF-1; RF-1 domain
    26. XM_017020861.2XP_016876350.1  peptide chain release factor 1, mitochondrial isoform X4

    27. XM_017020871.1XP_016876360.1  peptide chain release factor 1, mitochondrial isoform X6

    28. XM_017020859.2XP_016876348.1  peptide chain release factor 1, mitochondrial isoform X2

    29. XM_017020870.2XP_016876359.1  peptide chain release factor 1, mitochondrial isoform X6

    30. XM_024449444.1XP_024305212.1  peptide chain release factor 1, mitochondrial isoform X12

      Related
      ENSP00000399279.1, ENST00000452359.5
      Conserved Domains (1) summary
      cl23943
      Location:82234
      PCRF; PCRF domain
    31. XM_017020878.2XP_016876367.1  peptide chain release factor 1, mitochondrial isoform X11

    32. XM_011535326.3XP_011533628.1  peptide chain release factor 1, mitochondrial isoform X8

      Conserved Domains (2) summary
      pfam00472
      Location:344382
      RF-1; RF-1 domain
      pfam03462
      Location:151334
      PCRF; PCRF domain
    33. XM_017020872.1XP_016876361.1  peptide chain release factor 1, mitochondrial isoform X7

    34. XM_017020879.2XP_016876368.1  peptide chain release factor 1, mitochondrial isoform X12

      Conserved Domains (1) summary
      cl23943
      Location:82234
      PCRF; PCRF domain
    35. XM_011535327.2XP_011533629.1  peptide chain release factor 1, mitochondrial isoform X9

      Conserved Domains (1) summary
      pfam03462
      Location:151286
      PCRF; PCRF domain

    RNA

    1. XR_001749743.1 RNA Sequence

    2. XR_001749742.2 RNA Sequence

    3. XR_002957484.1 RNA Sequence

    4. XR_001749744.2 RNA Sequence

    5. XR_001749741.1 RNA Sequence

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