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    TNFSF8 TNF superfamily member 8 [ Homo sapiens (human) ]

    Gene ID: 944, updated on 13-May-2022

    Summary

    Official Symbol
    TNFSF8provided by HGNC
    Official Full Name
    TNF superfamily member 8provided by HGNC
    Primary source
    HGNC:HGNC:11938
    See related
    Ensembl:ENSG00000106952 MIM:603875; AllianceGenome:HGNC:11938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD153; CD30L; CD30LG; TNLG3A
    Summary
    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in lymph node (RPKM 9.3), appendix (RPKM 6.6) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TNFSF8 in Genome Data Viewer
    Location:
    9q32-q33.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (114893343..114930595, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (127085794..127123084, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117655623..117692875, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 4B pseudogene Neighboring gene Sharpr-MPRA regulatory region 6981 Neighboring gene tenascin C Neighboring gene uncharacterized LOC124902256 Neighboring gene uncharacterized LOC124902255 Neighboring gene uncharacterized LOC101928748

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of tumor necrosis factor ligand superfamily, member 8 (TNFSF8) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138144

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in CD8-positive, alpha-beta T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of T cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 8
    Names
    CD153 antigen
    CD30 antigen ligand
    CD30 ligand
    CD30-L
    tumor necrosis factor (ligand) superfamily, member 8
    tumor necrosis factor ligand 3A
    tumor necrosis factor superfamily member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244.4NP_001235.1  tumor necrosis factor ligand superfamily member 8 isoform 1

      See identical proteins and their annotated locations for NP_001235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA748015, AK313619, AL133412
      Consensus CDS
      CCDS6810.1
      UniProtKB/Swiss-Prot
      P32971
      UniProtKB/TrEMBL
      Q52M88
      Related
      ENSP00000223795.2, ENST00000223795.3
      Conserved Domains (1) summary
      pfam00229
      Location:113230
      TNF; TNF(tumor Necrosis Factor) family
    2. NM_001252290.1NP_001239219.1  tumor necrosis factor ligand superfamily member 8 isoform 2

      See identical proteins and their annotated locations for NP_001239219.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region of the last exon and contains an alternate downstream exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK313619, AW118787, BX108999, CD690231
      Consensus CDS
      CCDS75884.1
      UniProtKB/TrEMBL
      A0A087X228, Q52M88
      Related
      ENSP00000484651.1, ENST00000618336.4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      114893343..114930595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      127085794..127123084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)