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    CD101 CD101 molecule [ Homo sapiens (human) ]

    Gene ID: 9398, updated on 17-Sep-2024

    Summary

    Official Symbol
    CD101provided by HGNC
    Official Full Name
    CD101 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:5949
    See related
    Ensembl:ENSG00000134256 MIM:604516; AllianceGenome:HGNC:5949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    V7; IGSF2; EWI-101
    Summary
    Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within positive regulation of myeloid leukocyte differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in small intestine (RPKM 2.3), lung (RPKM 2.1) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CD101 in Genome Data Viewer
    Location:
    1p13.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (117001760..117036552)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (117000831..117046977)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117544382..117579174)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378927 Neighboring gene prostaglandin F2 receptor inhibitor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:117481416-117481965 Neighboring gene MPRA-validated peak385 silencer Neighboring gene RNA, 5S ribosomal pseudogene 55 Neighboring gene Sharpr-MPRA regulatory region 2959 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:117532703-117533902 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:117560254-117561453 Neighboring gene uncharacterized LOC124904386 Neighboring gene CD101 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1579 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:117619501-117620700 Neighboring gene transcription termination factor 2 Neighboring gene microRNA 942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1580 Neighboring gene tripartite motif containing 45

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD101 (IGSF2) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    immunoglobulin superfamily member 2
    Names
    cell surface glycoprotein V7
    glu-Trp-Ile EWI motif-containing protein 101
    leukocyte surface protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256106.3NP_001243035.1  immunoglobulin superfamily member 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001243035.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1, 2 and 3 all encode isoform 1.
      Source sequence(s)
      AL445231
      Consensus CDS
      CCDS891.1
      UniProtKB/Swiss-Prot
      Q15856, Q93033
      Related
      ENSP00000508039.1, ENST00000682167.1
      Conserved Domains (2) summary
      smart00410
      Location:87142
      IG_like; Immunoglobulin like
      cl11960
      Location:19142
      Ig; Immunoglobulin domain
    2. NM_001256109.3NP_001243038.1  immunoglobulin superfamily member 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001243038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1, 2 and 3 all encode isoform 1.
      Source sequence(s)
      AL445231
      Consensus CDS
      CCDS891.1
      UniProtKB/Swiss-Prot
      Q15856, Q93033
      Related
      ENSP00000358482.1, ENST00000369470.1
      Conserved Domains (2) summary
      smart00410
      Location:87142
      IG_like; Immunoglobulin like
      cl11960
      Location:19142
      Ig; Immunoglobulin domain
    3. NM_001256111.3NP_001243040.1  immunoglobulin superfamily member 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001243040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and also an alternate splice site in the 3' UTR, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL445231
      Conserved Domains (2) summary
      smart00410
      Location:762849
      IG_like; Immunoglobulin like
      cl11960
      Location:759849
      Ig; Immunoglobulin domain
    4. NM_004258.6NP_004249.2  immunoglobulin superfamily member 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004249.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 all encode isoform 1.
      Source sequence(s)
      AL445231
      Consensus CDS
      CCDS891.1
      UniProtKB/Swiss-Prot
      Q15856, Q93033
      Conserved Domains (2) summary
      smart00410
      Location:87142
      IG_like; Immunoglobulin like
      cl11960
      Location:19142
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      117001760..117036552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434715.1XP_047290671.1  immunoglobulin superfamily member 2 isoform X1

      Related
      ENSP00000256652.4, ENST00000256652.8
    2. XM_047434718.1XP_047290674.1  immunoglobulin superfamily member 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      117000831..117046977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339677.1XP_054195652.1  immunoglobulin superfamily member 2 isoform X2

    2. XM_054339676.1XP_054195651.1  immunoglobulin superfamily member 2 isoform X1