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    S1PR2 sphingosine-1-phosphate receptor 2 [ Homo sapiens (human) ]

    Gene ID: 9294, updated on 31-Mar-2024

    Summary

    Official Symbol
    S1PR2provided by HGNC
    Official Full Name
    sphingosine-1-phosphate receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:3169
    See related
    Ensembl:ENSG00000267534 MIM:605111; AllianceGenome:HGNC:3169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDG5; H218; LPB2; S1P2; AGR16; EDG-5; DFNB68; Gpcr13
    Summary
    This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
    Expression
    Broad expression in placenta (RPKM 10.4), lymph node (RPKM 5.1) and 22 other tissues See more
    Orthologs
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    Genomic context

    See S1PR2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10221433..10231331, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10347578..10357458, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10332109..10342007, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:10246117-10247316 Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10294611-10295111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13940 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10310838-10311338 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10330242-10330742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10330743-10331243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10340651-10341365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13947 Neighboring gene Sharpr-MPRA regulatory region 3154 Neighboring gene microRNA 4322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10060 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:10362245-10362818 and GRCh37_chr19:10362819-10363392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13951 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene Sharpr-MPRA regulatory region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13953 Neighboring gene lncRNA inflammatory and mucous response associated, antisense to ICAM1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13954 Neighboring gene intercellular adhesion molecule 1 Neighboring gene ICAM4 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: DNMT1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sphingosine-1-phosphate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphingosine-1-phosphate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sphingosine-1-phosphate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 2
    Names
    CTD-2369P2.2
    S1P receptor 2
    S1P receptor EDG5
    S1P receptor Edg-5
    deafness, autosomal recessive 68
    endothelial differentiation G-protein coupled receptor 5
    endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
    sphingosine 1-phosphate receptor Edg-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046802.1 RefSeqGene

      Range
      5477..15375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1356

    mRNA and Protein(s)

    1. NM_004230.4NP_004221.3  sphingosine 1-phosphate receptor 2

      See identical proteins and their annotated locations for NP_004221.3

      Status: REVIEWED

      Source sequence(s)
      AC011511, BC069598, BF513287, BG055846
      Consensus CDS
      CCDS12229.1
      UniProtKB/Swiss-Prot
      O95136, Q86UN8
      Related
      ENSP00000496438.1, ENST00000646641.1
      Conserved Domains (1) summary
      cd15347
      Location:34299
      7tmA_S1PR2_Edg5; sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10221433..10231331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10347578..10357458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)