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    CD8B CD8b molecule [ Homo sapiens (human) ]

    Gene ID: 926, updated on 11-Sep-2019

    Summary

    Official Symbol
    CD8Bprovided by HGNC
    Official Full Name
    CD8b moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1707
    See related
    Ensembl:ENSG00000172116 MIM:186730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LY3; P37; LEU2; LYT3; CD8B1
    Summary
    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
    Expression
    Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues See more
    Orthologs

    Genomic context

    See CD8B in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (86815337..86861924, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87042460..87089047, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene CD8A intronic regulatory region Neighboring gene uncharacterized LOC105374846 Neighboring gene CD8a molecule Neighboring gene anaphase promoting complex subunit 1 pseudogene 1 Neighboring gene WW domain binding protein 1 pseudogene Neighboring gene RANBP2 like and GRIP domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    Nef nef HIV-1 Nef downregulates surface expression of the beta-chain of the CD8 receptor by accelerated endocytosis; amino acid positions 57 to 58 and 174 to 175 in Nef are involved in the down modulation PubMed
    nef HIV-1 Nef interaction with AP-1gamma is required for CD28 and CD8beta downregulation PubMed
    nef Downregulation of CD8beta by HIV-1 Nef requires an intact AP-2 complex PubMed
    nef Co-localization of HIV-1 Nef and CD8beta is revealed by staining assays in 293T cells expressing both proteins PubMed
    Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC119115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class I protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    coreceptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of defense response to virus by virus TAS
    Traceable Author Statement
    more info
     
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    T cell receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome membrane TAS
    Traceable Author Statement
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD8 beta chain
    Names
    CD8 antigen, beta polypeptide 1 (p37)
    T lymphocyte surface glycoprotein beta chain

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178100.1NP_001171571.1  T-cell surface glycoprotein CD8 beta chain isoform 6 precursor

      See identical proteins and their annotated locations for NP_001171571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two exons in the 3' coding region, which results in a frameshift, compared to variant 2. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AW296309, BC100912, DC405359, X13445
      Consensus CDS
      CCDS54376.1
      UniProtKB/Swiss-Prot
      P10966
      Related
      ENSP00000377358.2, ENST00000393761.6
      Conserved Domains (2) summary
      cd07700
      Location:29134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26134
      IG_like; Immunoglobulin like
    2. NM_004931.5NP_004922.1  T-cell surface glycoprotein CD8 beta chain isoform 5 precursor

      See identical proteins and their annotated locations for NP_004922.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as M-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AC111200, BC100912, BP392114, DB223179, DC405359, X13444
      Consensus CDS
      CCDS1997.1
      UniProtKB/Swiss-Prot
      P10966
      Related
      ENSP00000375070.6, ENST00000390655.11
      Conserved Domains (2) summary
      cd07700
      Location:29134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26134
      IG_like; Immunoglobulin like
    3. NM_172101.4NP_742099.1  T-cell surface glycoprotein CD8 beta chain isoform 3 precursor

      See identical proteins and their annotated locations for NP_742099.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as M-3, includes an alternate exon in the 3' coding region, which results in a frameshift compared to variant 2. The resulting membrane associated protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AW296309, BC100912, DC405359, X13445
      Consensus CDS
      CCDS42708.1
      UniProtKB/Swiss-Prot
      P10966
      Related
      ENSP00000377356.2, ENST00000393759.6
      Conserved Domains (2) summary
      cd07700
      Location:29134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26134
      IG_like; Immunoglobulin like
    4. NM_172102.4NP_742100.1  T-cell surface glycoprotein CD8 beta chain isoform 4 precursor

      See identical proteins and their annotated locations for NP_742100.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as S-1, lacks an in-frame exon in the coding region, compared to variant 2. The resulting secreted protein (isoform 4) is shorter than isoform 2.
      Source sequence(s)
      AW296309, BC100912, DC405359, X13446
      Consensus CDS
      CCDS1994.1
      UniProtKB/Swiss-Prot
      P10966
      Related
      ENSP00000340592.3, ENST00000349455.7
      Conserved Domains (2) summary
      cd07700
      Location:29134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26134
      IG_like; Immunoglobulin like
    5. NM_172213.4NP_757362.1  T-cell surface glycoprotein CD8 beta chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_757362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AW296309, BC100912, BC100913, DC405359
      Consensus CDS
      CCDS1995.1
      UniProtKB/Swiss-Prot
      P10966
      Related
      ENSP00000331172.2, ENST00000331469.6
      Conserved Domains (1) summary
      cd07700
      Location:29134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      86815337..86861924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533164.2XP_011531466.1  T-cell surface glycoprotein CD8 beta chain isoform X1

      See identical proteins and their annotated locations for XP_011531466.1

      UniProtKB/TrEMBL
      Q53QL8
      Conserved Domains (2) summary
      cd07700
      Location:29134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26134
      IG_like; Immunoglobulin like

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172099.2: Suppressed sequence

      Description
      NM_172099.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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