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    RAB11B RAB11B, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 9230, updated on 12-Aug-2018

    Summary

    Official Symbol
    RAB11Bprovided by HGNC
    Official Full Name
    RAB11B, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9761
    See related
    Ensembl:ENSG00000185236 MIM:604198; Vega:OTTHUMG00000182278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H-YPT3; NDAGSCW
    Summary
    The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in fat (RPKM 36.5), thyroid (RPKM 36.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See RAB11B in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (8390321..8404434)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8455205..8469318)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene angiopoietin like 4 Neighboring gene RAB11B antisense RNA 1 Neighboring gene microRNA 4999 Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene heterogeneous nuclear ribonucleoprotein M

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
    nef HIV-1 Nef co-localization with Rab11A GTPase is revealed by staining in the peripheral and perinuclear compartments PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
      RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...
    • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
      TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
    • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC133246

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding HDA PubMed 
    myosin V binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    constitutive secretory pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    constitutive secretory pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    melanosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    receptor recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of anion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, endosome to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transferrin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    anchored component of synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    recycling endosome membrane TAS
    Traceable Author Statement
    more info
     
    synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-11B
    Names
    GTP-binding protein YPT3
    RAB11B, member of RAS oncogene family

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004218.3NP_004209.2  ras-related protein Rab-11B

      See identical proteins and their annotated locations for NP_004209.2

      Status: VALIDATED

      Source sequence(s)
      AK225036, AK225642, BP367041, BP396219, CX787570
      Consensus CDS
      CCDS12201.1
      UniProtKB/Swiss-Prot
      Q15907
      Related
      ENSP00000333547.5, OTTHUMP00000268811, ENST00000328024.10, OTTHUMT00000460343
      Conserved Domains (1) summary
      cd01868
      Location:9173
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      8390321..8404434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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