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    ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 [ Homo sapiens (human) ]

    Gene ID: 9181, updated on 6-Jan-2019

    Summary

    Official Symbol
    ARHGEF2provided by HGNC
    Official Full Name
    Rho/Rac guanine nucleotide exchange factor 2provided by HGNC
    Primary source
    HGNC:HGNC:682
    See related
    Ensembl:ENSG00000116584 MIM:607560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GEF; P40; GEFH1; LFP40; GEF-H1; NEDMHM
    Summary
    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
    Expression
    Ubiquitous expression in lung (RPKM 15.7), spleen (RPKM 12.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See ARHGEF2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (155946839..155991262, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155916431..155953396, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985207 Neighboring gene relaxin family peptide/INSL5 receptor 4 Neighboring gene microRNA 6738 Neighboring gene uncharacterized LOC107985209 Neighboring gene uncharacterized LOC107985210 Neighboring gene uncharacterized LOC107985208 Neighboring gene signal sequence receptor subunit 2 Neighboring gene uncharacterized LOC105371729

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with midbrain and hindbrain malformations
    MedGen: C4479613 OMIM: 617523 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ARHGEF2 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
      Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
    • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Reelin signaling pathway, organism-specific biosystem
      Reelin signaling pathway
    • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RAC1 activity, organism-specific biosystem
      Regulation of RAC1 activity
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ45440, KIAA0651, DKFZp547L106, DKFZp547P1516

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rac GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rac guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    asymmetric neuroblast division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular hyperosmotic response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of necroptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of podosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of Rho protein signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion HDA PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    podosome IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 2
    Names
    Rho/Rac guanine nucleotide exchange factor (GEF) 2
    guanine nucleotide exchange factor H1
    microtubule-regulated Rho-GEF
    proliferating cell nucleolar antigen p40

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162383.2NP_001155855.1  rho guanine nucleotide exchange factor 2 isoform 1

      See identical proteins and their annotated locations for NP_001155855.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL355388, BC020567, BC027722, CN388788
      Consensus CDS
      CCDS53376.1
      UniProtKB/Swiss-Prot
      Q92974
      Related
      ENSP00000354837.4, ENST00000361247.8
      Conserved Domains (4) summary
      cd00029
      Location:4085
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:236430
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:470585
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:473571
      PH; PH domain
    2. NM_001162384.1NP_001155856.1  rho guanine nucleotide exchange factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001155856.1

      Status: VALIDATED

      Description
      Transcript Variant: Thsi variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal amino acid, as compared to isoform 1.
      Source sequence(s)
      AF486838, AI925929, AL512715, BC020567, CN388788
      Consensus CDS
      CCDS53375.1
      UniProtKB/Swiss-Prot
      Q92974
      Related
      ENSP00000314787.4, ENST00000313667.8
      Conserved Domains (4) summary
      cd00029
      Location:4085
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:235429
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:469584
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:472570
      PH; PH domain
    3. NM_001350110.1NP_001337039.1  rho guanine nucleotide exchange factor 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon, resulting in a distinct 5' UTR, use of a downstream start codon, and uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and contains an internal segment compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
      Source sequence(s)
      AI925929, AL512715, AL527706, BM476546, BM552445, DA344419
      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:209403
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:443558
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:774846
      DUF390; Protein of unknown function (DUF390)
    4. NM_001350111.1NP_001337040.1  rho guanine nucleotide exchange factor 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' exon, resulting in a distinct 5' UTR, use of a downstream start codon, and uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and contains an internal segment compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
      Source sequence(s)
      AI925929, AL512715, AL527706, BM146462, BM476546, BM552445, HY130236
      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:209403
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:443558
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:774846
      DUF390; Protein of unknown function (DUF390)
    5. NM_001350112.1NP_001337041.1  rho guanine nucleotide exchange factor 2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate 5' exon, resulting in a distinct 5' UTR, use of an alternate start codon, and uses an alternate in-frame slice site in the 3' coding region. The resulting isoform (5) has a shorter N-terminus, and contains an internal segment compared to isoform 1.
      Source sequence(s)
      AI925929, AL355388, AL512715, AL527706, BF349572, BM476546, BM552445
      Conserved Domains (4) summary
      cd00029
      Location:2368
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:218412
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:452567
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:783855
      DUF390; Protein of unknown function (DUF390)
    6. NM_004723.3NP_004714.2  rho guanine nucleotide exchange factor 2 isoform 3

      See identical proteins and their annotated locations for NP_004714.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AI925929, AL512715, CN264153
      Consensus CDS
      CCDS1125.1
      UniProtKB/Swiss-Prot
      Q92974
      Related
      ENSP00000315325.7, ENST00000313695.11
      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:208402
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:442557
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:445543
      PH; PH domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      155946839..155991262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450823.1XP_024306591.1  rho guanine nucleotide exchange factor 2 isoform X14

      Conserved Domains (3) summary
      cd00160
      Location:159353
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:393508
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:724796
      DUF390; Protein of unknown function (DUF390)
    2. XM_024450815.1XP_024306583.1  rho guanine nucleotide exchange factor 2 isoform X13

      Conserved Domains (3) summary
      cd00160
      Location:160354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:394509
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:725797
      DUF390; Protein of unknown function (DUF390)
    3. XM_005245591.4XP_005245648.1  rho guanine nucleotide exchange factor 2 isoform X9

      See identical proteins and their annotated locations for XP_005245648.1

      Conserved Domains (4) summary
      cd00029
      Location:2570
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:221415
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:455570
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:458556
      PH; PH domain
    4. XM_005245590.4XP_005245647.1  rho guanine nucleotide exchange factor 2 isoform X9

      See identical proteins and their annotated locations for XP_005245647.1

      Conserved Domains (4) summary
      cd00029
      Location:2570
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:221415
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:455570
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:458556
      PH; PH domain
    5. XM_005245588.3XP_005245645.1  rho guanine nucleotide exchange factor 2 isoform X6

      Conserved Domains (4) summary
      cd00029
      Location:4085
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:235429
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:469584
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:472570
      PH; PH domain
    6. XM_005245587.3XP_005245644.1  rho guanine nucleotide exchange factor 2 isoform X5

      Conserved Domains (4) summary
      cd00029
      Location:4085
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:236430
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:470585
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:473571
      PH; PH domain
    7. XM_006711623.4XP_006711686.1  rho guanine nucleotide exchange factor 2 isoform X13

      See identical proteins and their annotated locations for XP_006711686.1

      Conserved Domains (3) summary
      cd00160
      Location:160354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:394509
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:725797
      DUF390; Protein of unknown function (DUF390)
    8. XM_017002797.2XP_016858286.1  rho guanine nucleotide exchange factor 2 isoform X12

    9. XM_006711625.4XP_006711688.1  rho guanine nucleotide exchange factor 2 isoform X13

      See identical proteins and their annotated locations for XP_006711688.1

      Conserved Domains (3) summary
      cd00160
      Location:160354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:394509
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:725797
      DUF390; Protein of unknown function (DUF390)
    10. XM_006711626.3XP_006711689.1  rho guanine nucleotide exchange factor 2 isoform X13

      See identical proteins and their annotated locations for XP_006711689.1

      Conserved Domains (3) summary
      cd00160
      Location:160354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:394509
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:725797
      DUF390; Protein of unknown function (DUF390)
    11. XM_005245594.3XP_005245651.1  rho guanine nucleotide exchange factor 2 isoform X11

      See identical proteins and their annotated locations for XP_005245651.1

      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:209403
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:443558
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:774846
      DUF390; Protein of unknown function (DUF390)
    12. XM_005245589.5XP_005245646.1  rho guanine nucleotide exchange factor 2 isoform X7

      Conserved Domains (4) summary
      cd00029
      Location:3277
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:228422
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:462577
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:465563
      PH; PH domain
    13. XM_017002795.2XP_016858284.1  rho guanine nucleotide exchange factor 2 isoform X8

    14. XM_011510143.3XP_011508445.1  rho guanine nucleotide exchange factor 2 isoform X15

      Conserved Domains (3) summary
      cd00160
      Location:57251
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:291406
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:294392
      PH; PH domain
    15. XM_017002794.2XP_016858283.1  rho guanine nucleotide exchange factor 2 isoform X4

    16. XM_011510136.3XP_011508438.2  rho guanine nucleotide exchange factor 2 isoform X2

    17. XM_011510137.3XP_011508439.2  rho guanine nucleotide exchange factor 2 isoform X3

      Related
      ENSP00000476916.1, ENST00000462460.6
    18. XM_011510139.3XP_011508441.1  rho guanine nucleotide exchange factor 2 isoform X1

      Conserved Domains (4) summary
      cd00029
      Location:183228
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:379573
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:613728
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:616714
      PH; PH domain
    19. XM_017002798.2XP_016858287.1  rho guanine nucleotide exchange factor 2 isoform X13

      Conserved Domains (3) summary
      cd00160
      Location:160354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:394509
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:725797
      DUF390; Protein of unknown function (DUF390)
    20. XM_006711622.4XP_006711685.1  rho guanine nucleotide exchange factor 2 isoform X10

      Conserved Domains (4) summary
      cd00029
      Location:2368
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:219413
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:453568
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:456554
      PH; PH domain
    21. XM_006711624.4XP_006711687.1  rho guanine nucleotide exchange factor 2 isoform X13

      See identical proteins and their annotated locations for XP_006711687.1

      Conserved Domains (3) summary
      cd00160
      Location:160354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:394509
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cl25642
      Location:725797
      DUF390; Protein of unknown function (DUF390)
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