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    CCRL2 C-C motif chemokine receptor like 2 [ Homo sapiens (human) ]

    Gene ID: 9034, updated on 17-Jun-2024

    Summary

    Official Symbol
    CCRL2provided by HGNC
    Official Full Name
    C-C motif chemokine receptor like 2provided by HGNC
    Primary source
    HGNC:HGNC:1612
    See related
    Ensembl:ENSG00000121797 MIM:608379; AllianceGenome:HGNC:1612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B
    Summary
    This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 6.4), lung (RPKM 6.3) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCRL2 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (46407259..46409523)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (46422959..46425353)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46448750..46451014)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 2 Neighboring gene CCR5 antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14288 Neighboring gene NANOG hESC enhancer GRCh37_chr3:46421718-46422219 Neighboring gene C-C motif chemokine receptor 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46434353-46434852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14289 Neighboring gene long intergenic non-protein coding RNA 2009 Neighboring gene Sharpr-MPRA regulatory region 12992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46484307-46484808 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46491889-46492388 Neighboring gene lactotransferrin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46497203-46497704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46497705-46498204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46511713-46512212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46519415-46519916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46519917-46520416

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study implicates PARD3B-based AIDS restriction.
    EBI GWAS Catalog
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of chemokine (C-C motif) receptor-like 2 (CCRL2) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ55815, MGC34104, MGC116710

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR chemokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables chemokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-C chemokine receptor-like 2
    Names
    atypical chemokine receptor 5
    chemokine (C-C motif) receptor-like 2
    chemokine receptor CCR11
    chemokine receptor X
    putative MCP-1 chemokine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130910.2NP_001124382.1  C-C chemokine receptor-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001124382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1, resulting in a longer isoform (2) that has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC098613, AF015524, AK296673
      Consensus CDS
      CCDS46814.1
      UniProtKB/Swiss-Prot
      O00421
      Related
      ENSP00000349967.4, ENST00000357392.4
      Conserved Domains (1) summary
      PHA03087
      Location:34333
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
    2. NM_003965.5NP_003956.2  C-C chemokine receptor-like 2 isoform 1

      See identical proteins and their annotated locations for NP_003956.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript but encodes the longer isoform (1).
      Source sequence(s)
      AF015525, BC071682
      Consensus CDS
      CCDS43079.1
      UniProtKB/Swiss-Prot
      B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
      UniProtKB/TrEMBL
      A0A024R2R2, A8MXI2, B2R8C0
      Related
      ENSP00000381994.3, ENST00000399036.4
      Conserved Domains (1) summary
      PHA03087
      Location:22321
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      46407259..46409523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534208.2XP_011532510.1  C-C chemokine receptor-like 2 isoform X1

      See identical proteins and their annotated locations for XP_011532510.1

      UniProtKB/Swiss-Prot
      B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
      UniProtKB/TrEMBL
      A0A024R2R2, A8MXI2, B2R8C0
      Related
      ENSP00000383678.2, ENST00000400882.2
      Conserved Domains (1) summary
      PHA03087
      Location:22321
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      46422959..46425353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348324.1XP_054204299.1  C-C chemokine receptor-like 2 isoform X1

      UniProtKB/Swiss-Prot
      B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
      UniProtKB/TrEMBL
      A0A024R2R2, A8MXI2, B2R8C0
    2. XM_054348325.1XP_054204300.1  C-C chemokine receptor-like 2 isoform X1

      UniProtKB/Swiss-Prot
      B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
      UniProtKB/TrEMBL
      A0A024R2R2, A8MXI2, B2R8C0