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    KBTBD6 kelch repeat and BTB domain containing 6 [ Homo sapiens (human) ]

    Gene ID: 89890, updated on 5-Aug-2018

    Summary

    Official Symbol
    KBTBD6provided by HGNC
    Official Full Name
    kelch repeat and BTB domain containing 6provided by HGNC
    Primary source
    HGNC:HGNC:25340
    See related
    Ensembl:ENSG00000165572 MIM:617738; Vega:OTTHUMG00000016786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Orthologs

    Genomic context

    See KBTBD6 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (41127573..41132800, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41701709..41706936, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene microRNA 3168 Neighboring gene RNA, 7SL, cytoplasmic 597, pseudogene Neighboring gene uncharacterized LOC101929140 Neighboring gene calmodulin 2 pseudogene 3 Neighboring gene kelch repeat and BTB domain containing 7

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ58260, DKFZp547M073, DKFZp547E1912

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    kelch repeat and BTB domain-containing protein 6
    Names
    kelch repeat and BTB (POZ) domain containing 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152903.4NP_690867.3  kelch repeat and BTB domain-containing protein 6

      See identical proteins and their annotated locations for NP_690867.3

      Status: VALIDATED

      Source sequence(s)
      AK023475, AL354696, BC000560, BC051349, BU928896, CD109431, CD557535
      Consensus CDS
      CCDS9376.1
      UniProtKB/Swiss-Prot
      Q86V97
      Related
      ENSP00000368799.1, OTTHUMP00000018312, ENST00000379485.1, OTTHUMT00000044657
      Conserved Domains (2) summary
      sd00038
      Location:425471
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:55553
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      41127573..41132800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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