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    Lrp3 LDL receptor related protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89787, updated on 10-Jul-2024

    Summary

    Official Symbol
    Lrp3provided by RGD
    Official Full Name
    LDL receptor related protein 3provided by RGD
    Primary source
    RGD:619729
    See related
    EnsemblRapid:ENSRNOG00000011451 AllianceGenome:RGD:619729
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in clathrin-coated pit. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human LRP3 (LDL receptor related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 88.9), Brain (RPKM 78.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Lrp3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (96980762..96996157, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (87843815..87859147, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91447308..91462603, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555770 Neighboring gene uncharacterized LOC134483098 Neighboring gene solute carrier family 7 member 10 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transfer RNA threonine (anticodon AGU) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 3
    Names
    105 kDa low-density lipoprotein receptor-related protein
    LRP-3
    rLRp105

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053541.2NP_445993.1  low-density lipoprotein receptor-related protein 3 precursor

      See identical proteins and their annotated locations for NP_445993.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88204
      UniProtKB/TrEMBL
      A0A8L2Q7D1
      Related
      ENSRNOP00000082642.2, ENSRNOT00000111284.2
      Conserved Domains (2) summary
      cd00041
      Location:43156
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:166200
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      96980762..96996157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092968.2XP_038948896.1  low-density lipoprotein receptor-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q7D1
      Related
      ENSRNOP00000015384.3, ENSRNOT00000015384.4
      Conserved Domains (2) summary
      cd00041
      Location:43156
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:166200
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RNA

    1. XR_005493688.2 RNA Sequence

    2. XR_005493687.2 RNA Sequence