HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HERC2provided by HGNC
Official Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by HGNC
Primary source: HGNC:HGNC:4868
See related: Ensembl:ENSG00000128731 MIM:605837; Vega:OTTHUMG00000129251
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: jdf2; p528; MRT38; SHEP1; D15F37S1
Summary: This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
Expression: Ubiquitous expression in brain (RPKM 8.9), ovary (RPKM 8.1) and 25 other tissues See more
Orthologs: all

Genomic context

Location:: 15q13.1

Exon count:: 98

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	15	NC_000015.10 (28111037..28322173, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (28356183..28567313, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

The results of this study are the first to show an association between HERC2 variants and time to first cSCC post-transplant.
Title: Variants at the OCA2/HERC2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs.
By downregulating acetylated LKB1 protein via HERC2, SIRT1 fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis
Title: Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.
Evaluated the association of seven OCA2-HERC2 SNPs and haplotypes with pigmentation characteristics (eye, skin, hair and freckles) in the highly admixed and phenotypically heterogeneous Brazilian population. Such SNPs and haplotypes could be deemed as good predictors for the presence of freckles and for skin, eye and hair pigmentation in the Brazilian population.
Title: Associations of OCA2-HERC2 SNPs and haplotypes with human pigmentation characteristics in the Brazilian population.
We showed that loss of HERC2 function leads to the accumulation of XPA and BRCA1 in the patient's fibroblasts and generates decreased sensitivity to apoptosis and increased level of DNA repair
Title: Complete loss of function of the ubiquitin ligase HERC2 causes a severe neurodevelopmental phenotype.
SNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less predictive.
Title: The more the merrier? How a few SNPs predict pigmentation phenotypes in the Northern German population.
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Title: Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.
Title: The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.
Results identify HERC2 as a regulator of p53 signaling.
Title: The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization.
results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism
Title: HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33.
Title: Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Mental retardation, autosomal recessive 38 MedGen: C3809753 OMIM: 615516 GeneReviews: Not available	Compare labs
Prader-Willi syndrome MedGen: C0032897 OMIM: 176270 GeneReviews: Prader-Willi Syndrome	Compare labs
Skin/hair/eye pigmentation, variation in, 1 MedGen: C1856895 OMIM: 227220 GeneReviews: Not available	Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Digital quantification of human eye color highlights genetic association of three new loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetic determinants of hair, eye and skin pigmentation in Europeans. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
The CCND1 c.870G&gt;A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Web-based, participant-driven studies yield novel genetic associations for common traits. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with hect domain and RLD 2 (HERC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
DNA Double Strand Break Response, organism-specific biosystem (from REACTOME)
DNA Double Strand Break Response, organism-specific biosystemDNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signali...
DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
G2/M Checkpoints, organism-specific biosystem (from REACTOME)
G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
G2/M DNA damage checkpoint, organism-specific biosystem (from REACTOME)
G2/M DNA damage checkpoint, organism-specific biosystemThroughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or i...
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM fol...
Homology Directed Repair, organism-specific biosystem (from REACTOME)
Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Nonhomologous End-Joining (NHEJ), organism-specific biosystem (from REACTOME)
Nonhomologous End-Joining (NHEJ), organism-specific biosystemThe nonhomologous end joining (NHEJ) pathway is initiated in response to the formation of DNA double-strand breaks (DSBs) induced by DNA-damaging agents, such as ionizing radiation. DNA DSBs are reco...
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
Processing of DNA double-strand break ends, organism-specific biosystem (from REACTOME)
Processing of DNA double-strand break ends, organism-specific biosystemHomology directed repair (HDR) through homologous recombination (HRR) or single strand annealing (SSA) requires extensive resection of DNA double strand break (DSB) ends (Thompson and Limoli 2003, Ci...
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, organism-specific biosystem (from REACTOME)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, organism-specific biosystemActivated ATM phosphorylates a number of proteins involved in the DNA damage checkpoint and DNA repair (Thompson and Schild 2002, Ciccia and Elledge 2010), thereby triggering and coordinating accumul...
SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
SUMOylation, organism-specific biosystem (from REACTOME)
SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC311424P1 (e-PCR)
- UniSTS:272901

PMC311424P2 (e-PCR)
- UniSTS:272902

SHGC-148873 (e-PCR)
- UniSTS:176658

RH48411 (e-PCR)
- UniSTS:67618

D11S2560 (e-PCR)
- UniSTS:37928

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-104948 (e-PCR)
- UniSTS:169042

D15S1477 (e-PCR)
- UniSTS:474482

D15S737 (e-PCR)
- UniSTS:51634

RH11271 (e-PCR)
- UniSTS:24060

Homology

Homologs of the HERC2 gene: The HERC2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 138 organisms have orthologs with human gene HERC2
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
SUMO binding	IDA Inferred from Direct Assay more info	PubMed
guanyl-nucleotide exchange factor activity	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cellular response to DNA damage stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed
double-strand break repair via nonhomologous end joining	TAS Traceable Author Statement more info
intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein ubiquitination	IEA Inferred from Electronic Annotation more info
spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centriole	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
membrane	HDA more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase HERC2

Names: HECT-type E3 ubiquitin transferase HERC2; hect domain and RCC1-like domain-containing protein 2; hect domain and RLD 2; probable E3 ubiquitin-protein ligase HERC2

NP_004658.3

EC 2.3.2.26

XP_005268333.1

EC 2.3.2.26

XP_006720789.1

EC 2.3.2.26

XP_006720790.1

EC 2.3.2.26

XP_016878184.1

EC 2.3.2.26

XP_016878185.1

EC 2.3.2.26

XP_016878186.1

EC 2.3.2.26

XP_016878187.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016355.1 RefSeqGene

Range

4998..216113

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004667.5 → NP_004658.3 E3 ubiquitin-protein ligase HERC2

See identical proteins and their annotated locations for NP_004658.3

Status: REVIEWED

Source sequence(s)

AC126332, AC135329, AF071172, AI820017, AK122977, AU100235, AW897649, BC148318, BX440995, CF135750, CX784863, DA868501

Consensus CDS

CCDS10021.1

UniProtKB/Swiss-Prot

O95714

UniProtKB/TrEMBL

A8KAQ8

Related

ENSP00000261609.7, OTTHUMP00000159564, ENST00000261609.11, OTTHUMT00000251358

Conserved Domains (10) summary

cd08664
Location:2765 → 2910

APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)

smart00119
Location:4464 → 4790

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4421 → 4792

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd02344
Location:2706 → 2750

ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...

cd14402
Location:2460 → 2507

UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

pfam00173
Location:1209 → 1282

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

pfam00415
Location:675 → 724

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam06701
Location:1870 → 1929

MIB_HERC2; Mib_herc2

pfam11515
Location:2554 → 2631

Cul7; Mouse development and cellular proliferation protein Cullin-7

pfam13540
Location:4039 → 4069

RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p12 Primary Assembly

Range

28111037..28322173 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006720727.3 → XP_006720790.1 E3 ubiquitin-protein ligase HERC2 isoform X3

See identical proteins and their annotated locations for XP_006720790.1

Conserved Domains (10) summary

cd08664
Location:2679 → 2824

APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)

smart00119
Location:4378 → 4704

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4335 → 4706

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd02344
Location:2620 → 2664

ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...

cd14402
Location:2374 → 2421

UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

pfam00173
Location:1123 → 1196

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

pfam00415
Location:589 → 638

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam06701
Location:1784 → 1843

MIB_HERC2; Mib_herc2

pfam11515
Location:2468 → 2545

Cul7; Mouse development and cellular proliferation protein Cullin-7

pfam13540
Location:3953 → 3983

RCC1_2; Regulator of chromosome condensation (RCC1) repeat
XM_006720726.3 → XP_006720789.1 E3 ubiquitin-protein ligase HERC2 isoform X1

See identical proteins and their annotated locations for XP_006720789.1

Conserved Domains (10) summary

cd08664
Location:2760 → 2905

APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)

smart00119
Location:4459 → 4785

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4416 → 4787

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd02344
Location:2701 → 2745

ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...

cd14402
Location:2455 → 2502

UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

pfam00173
Location:1204 → 1277

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

pfam00415
Location:675 → 724

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam06701
Location:1865 → 1924

MIB_HERC2; Mib_herc2

pfam11515
Location:2549 → 2626

Cul7; Mouse development and cellular proliferation protein Cullin-7

pfam13540
Location:4034 → 4064

RCC1_2; Regulator of chromosome condensation (RCC1) repeat
XM_005268276.5 → XP_005268333.1 E3 ubiquitin-protein ligase HERC2 isoform X2

See identical proteins and their annotated locations for XP_005268333.1

Conserved Domains (10) summary

cd08664
Location:2727 → 2872

APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)

smart00119
Location:4426 → 4752

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4383 → 4754

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd02344
Location:2668 → 2712

ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...

cd14402
Location:2422 → 2469

UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

pfam00173
Location:1171 → 1244

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

pfam00415
Location:637 → 686

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam06701
Location:1832 → 1891

MIB_HERC2; Mib_herc2

pfam11515
Location:2516 → 2593

Cul7; Mouse development and cellular proliferation protein Cullin-7

pfam13540
Location:4001 → 4031

RCC1_2; Regulator of chromosome condensation (RCC1) repeat
XM_017022695.1 → XP_016878184.1 E3 ubiquitin-protein ligase HERC2 isoform X2

Conserved Domains (10) summary

cd08664
Location:2727 → 2872

APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)

smart00119
Location:4426 → 4752

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4383 → 4754

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd02344
Location:2668 → 2712

ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...

cd14402
Location:2422 → 2469

UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

pfam00173
Location:1171 → 1244

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

pfam00415
Location:637 → 686

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam06701
Location:1832 → 1891

MIB_HERC2; Mib_herc2

pfam11515
Location:2516 → 2593

Cul7; Mouse development and cellular proliferation protein Cullin-7

pfam13540
Location:4001 → 4031

RCC1_2; Regulator of chromosome condensation (RCC1) repeat
XM_017022696.1 → XP_016878185.1 E3 ubiquitin-protein ligase HERC2 isoform X2

Conserved Domains (10) summary

cd08664
Location:2727 → 2872

APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)

smart00119
Location:4426 → 4752

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:4383 → 4754

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd02344
Location:2668 → 2712

ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...

cd14402
Location:2422 → 2469

UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

pfam00173
Location:1171 → 1244

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

pfam00415
Location:637 → 686

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam06701
Location:1832 → 1891

MIB_HERC2; Mib_herc2

pfam11515
Location:2516 → 2593

Cul7; Mouse development and cellular proliferation protein Cullin-7

pfam13540
Location:4001 → 4031

RCC1_2; Regulator of chromosome condensation (RCC1) repeat
XM_017022697.1 → XP_016878186.1 E3 ubiquitin-protein ligase HERC2 isoform X4
XM_017022698.1 → XP_016878187.1 E3 ubiquitin-protein ligase HERC2 isoform X4