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    ARHGEF7 Rho guanine nucleotide exchange factor 7 [ Homo sapiens (human) ]

    Gene ID: 8874, updated on 13-Feb-2019

    Summary

    Official Symbol
    ARHGEF7provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 7provided by HGNC
    Primary source
    HGNC:HGNC:15607
    See related
    Ensembl:ENSG00000102606 MIM:605477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314
    Summary
    This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in brain (RPKM 14.7), fat (RPKM 11.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See ARHGEF7 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (111114619..111305734)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111767624..111958081)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370364 Neighboring gene long intergenic non-protein coding RNA 431 Neighboring gene long intergenic non-protein coding RNA 368 Neighboring gene ARHGEF7 antisense RNA 2 Neighboring gene uncharacterized LOC101060553 Neighboring gene ARHGEF7 antisense RNA 1 Neighboring gene spalt like transcription factor 4 pseudogene 4 Neighboring gene uncharacterized LOC105370365 Neighboring gene testis expressed 29 Neighboring gene uncharacterized LOC107984618

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association meta-analysis for total serum bilirubin levels.
    NHGRI GWA Catalog
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    NHGRI GWA Catalog
    Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
    NHGRI GWA Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef In the presence of Nef, lipid raft Cdc42 is activated and forms a ternary complex between the c-Cbl-interacting protein p85Cool-1/betaPix and c-Cbl, displacing UbcH7 from rafts PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0142, KIAA0412, DKFZp761K1021, DKFZp686C12170

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    focal adhesion assembly HDA PubMed 
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity HMP PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of fibroblast migration HDA PubMed 
    positive regulation of growth hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lamellipodium morphogenesis HMP PubMed 
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading HMP PubMed 
    regulation of GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    focal adhesion HDA PubMed 
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    storage vacuole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 7
    Names
    PAK-interacting exchange factor beta
    Rho guanine nucleotide exchange factor (GEF) 7
    SH3 domain-containing proline-rich protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113511.2NP_001106983.1  rho guanine nucleotide exchange factor 7 isoform c

      See identical proteins and their annotated locations for NP_001106983.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes isoform c.
      Source sequence(s)
      AB177848, AK093326, AL353704, BC060776, BM677392, DB180957
      Consensus CDS
      CCDS45068.1
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      Q5W9H1
      Related
      ENSP00000364893.2, ENST00000375741.6
      Conserved Domains (7) summary
      cd12061
      Location:188241
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:272449
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:480578
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:634732
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:138184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:21128
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl26464
      Location:583664
      Atrophin-1; Atrophin-1 family
    2. NM_001113512.2NP_001106984.1  rho guanine nucleotide exchange factor 7 isoform d

      See identical proteins and their annotated locations for NP_001106984.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting protein (isoform d) is shorter than isoform c.
      Source sequence(s)
      AB177848, AK093326, AL353704, BC033905, BC060776, BM677392, DB180957
      Consensus CDS
      CCDS45069.1
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      Q5W9H1
      Related
      ENSP00000364891.2, ENST00000375739.6
      Conserved Domains (7) summary
      cd12061
      Location:138191
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      smart00033
      Location:2175
      CH; Calponin homology domain
      cd00160
      Location:222399
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:430528
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:448528
      PH; PH domain
      pfam16614
      Location:584682
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:88134
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    3. NM_001113513.1NP_001106985.1  rho guanine nucleotide exchange factor 7 isoform a

      See identical proteins and their annotated locations for NP_001106985.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AA457036, BC050521, CF121796, CF144155, D63476, DA216264
      Consensus CDS
      CCDS9521.1
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      A0A024RDY9
      Related
      ENSP00000397068.2, ENST00000426073.6
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:557643
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    4. NM_001320851.1NP_001307780.1  rho guanine nucleotide exchange factor 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AA457036, AB177849, AL390754, BC050521, CF121796, CF144155, D63476, DA404477, DA439385
      Consensus CDS
      CCDS9521.1
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      A0A024RDY9
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:557643
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    5. NM_001320852.1NP_001307781.1  rho guanine nucleotide exchange factor 7 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (e) lacks a portion of the N-terminus and has a longer, distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Conserved Domains (8) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:21107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:477557
      PH; PH domain
      pfam16523
      Location:714800
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:613711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    6. NM_001320853.1NP_001307782.1  rho guanine nucleotide exchange factor 7 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (f) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AA457036, AK300272, BC050521, CF121796, CF144155, DC318118
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      B7Z6G2
      Conserved Domains (7) summary
      cd12061
      Location:85138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:395475
      PH; PH domain
      pfam16523
      Location:632718
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:531629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:3581
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    7. NM_001320854.1NP_001307783.1  rho guanine nucleotide exchange factor 7 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (g) has a distinct, shorter N-terminus, compared to isoform c.
      Source sequence(s)
      AK093326, AK295472, AK308897, BC060776, BM677392, DB180957
      Consensus CDS
      CCDS81781.1
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      B7Z344, E9PDQ5
      Related
      ENSP00000417596.1, ENST00000478679.5
      Conserved Domains (4) summary
      cd00160
      Location:16193
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:224322
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:242322
      PH; PH domain
      pfam16614
      Location:378476
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    8. NM_001330597.1NP_001317526.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
      Source sequence(s)
      AB075521, AL139086, AL390754, AW872844, BC060776, D63476, DA404477, DA439385
      Consensus CDS
      CCDS86362.1
      UniProtKB/Swiss-Prot
      Q14155
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    9. NM_001330598.1NP_001317527.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
      Source sequence(s)
      AB075521, AB177849, AL139086, AL390754, AW872844, BC060776, D63476, DA404477, DA439385
      Consensus CDS
      CCDS86362.1
      UniProtKB/Swiss-Prot
      Q14155
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    10. NM_001354046.1NP_001340975.1  rho guanine nucleotide exchange factor 7 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) encodes the longest isoform (i).
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86360.1
      Related
      ENSP00000495631.1, ENST00000646102.1
      Conserved Domains (8) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:21107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:773859
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:613711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl26464
      Location:562643
      Atrophin-1; Atrophin-1 family
    11. NM_001354047.1NP_001340976.1  rho guanine nucleotide exchange factor 7 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL139086, AL353704, AL390754
      Conserved Domains (6) summary
      cd12061
      Location:95148
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      smart00033
      Location:2196
      CH; Calponin homology domain
      cd00160
      Location:179356
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:387485
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:541639
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:490571
      Atrophin-1; Atrophin-1 family
    12. NM_001354048.1NP_001340977.1  rho guanine nucleotide exchange factor 7 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 15-17, encodes isoform k.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86361.1
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:616702
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    13. NM_001354049.1NP_001340978.1  rho guanine nucleotide exchange factor 7 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 14, 16, and 17, encodes isoform k.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86361.1
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:616702
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    14. NM_001354050.1NP_001340979.1  rho guanine nucleotide exchange factor 7 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 14, 15, and 17, encodes isoform k.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86361.1
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:616702
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    15. NM_001354051.1NP_001340980.1  rho guanine nucleotide exchange factor 7 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 14-16, encodes isoform k.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86361.1
      Related
      ENSP00000218789.5, ENST00000218789.9
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:616702
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    16. NM_001354052.1NP_001340981.1  rho guanine nucleotide exchange factor 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 1, 5, 6, and 19, encodes isoform a.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS9521.1
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:557643
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    17. NM_001354053.1NP_001340982.1  rho guanine nucleotide exchange factor 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 1, 5, 6, and 18, encodes isoform a.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS9521.1
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:557643
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    18. NM_001354054.1NP_001340983.1  rho guanine nucleotide exchange factor 7 isoform l

      Status: REVIEWED

      Source sequence(s)
      AL139086, AL353704, AL390754
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407490
      Atrophin-1; Atrophin-1 family
    19. NM_001354055.1NP_001340984.1  rho guanine nucleotide exchange factor 7 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL139086
      Conserved Domains (5) summary
      cd00160
      Location:16193
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:224322
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:538624
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:378476
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:327408
      Atrophin-1; Atrophin-1 family
    20. NM_001354056.1NP_001340985.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 10, 11, and 23-26, encodes isoform h.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86362.1
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    21. NM_001354057.1NP_001340986.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 10, 11, 22, and 24-26, encodes isoform h.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86362.1
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    22. NM_001354058.1NP_001340987.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 10, 11, 22, 23, 25, and 26, encodes isoform h.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86362.1
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    23. NM_001354059.1NP_001340988.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 10, 11, 22-24, and 26, encodes isoform h.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86362.1
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    24. NM_001354060.1NP_001340989.1  rho guanine nucleotide exchange factor 7 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 10, 11, and 22-25, encodes isoform h.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS86362.1
      Related
      ENSP00000364875.1, ENST00000375723.5
      Conserved Domains (5) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    25. NM_001354061.1NP_001340990.1  rho guanine nucleotide exchange factor 7 isoform n

      Status: REVIEWED

      Source sequence(s)
      AL139086
      Conserved Domains (4) summary
      cd00160
      Location:20147
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:178276
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:332430
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:283366
      Atrophin-1; Atrophin-1 family
    26. NM_003899.4NP_003890.1  rho guanine nucleotide exchange factor 7 isoform a

      See identical proteins and their annotated locations for NP_003890.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AL139086, AL353704, AL390754
      Consensus CDS
      CCDS9521.1
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      A0A024RDY9
      Related
      ENSP00000364888.4, ENST00000375736.8
      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:557643
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:405486
      Atrophin-1; Atrophin-1 family
    27. NM_145735.3NP_663788.1  rho guanine nucleotide exchange factor 7 isoform b

      See identical proteins and their annotated locations for NP_663788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 3. The resulting protein (isoform b) is shorter than isoform c.
      Source sequence(s)
      AB177848, AK093326, AL353704, AL834228, BC060776, BM677392, DB180957
      Consensus CDS
      CCDS32009.1
      UniProtKB/Swiss-Prot
      Q14155
      UniProtKB/TrEMBL
      Q5W9H1
      Related
      ENSP00000325994.5, ENST00000317133.9
      Conserved Domains (7) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:21107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:477557
      PH; PH domain
      pfam16614
      Location:613711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      111114619..111305734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020815.1XP_016876304.1  rho guanine nucleotide exchange factor 7 isoform X3

    2. XM_006719956.3XP_006720019.1  rho guanine nucleotide exchange factor 7 isoform X1

      Conserved Domains (8) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:21107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:477557
      PH; PH domain
      pfam16523
      Location:726812
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:613723
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    3. XM_017020814.1XP_016876303.1  rho guanine nucleotide exchange factor 7 isoform X2

    4. XM_011521133.2XP_011519435.1  rho guanine nucleotide exchange factor 7 isoform X7

      Conserved Domains (5) summary
      cd12061
      Location:167220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:21107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16615
      Location:117163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl17171
      Location:459503
      PH-like; Pleckstrin homology-like domain
    5. XM_017020822.1XP_016876311.1  rho guanine nucleotide exchange factor 7 isoform X5

      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407490
      Atrophin-1; Atrophin-1 family
    6. XM_024449428.1XP_024305196.1  rho guanine nucleotide exchange factor 7 isoform X5

      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407490
      Atrophin-1; Atrophin-1 family
    7. XM_017020821.2XP_016876310.1  rho guanine nucleotide exchange factor 7 isoform X5

      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407490
      Atrophin-1; Atrophin-1 family
    8. XM_017020823.2XP_016876312.1  rho guanine nucleotide exchange factor 7 isoform X5

      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407490
      Atrophin-1; Atrophin-1 family
    9. XM_017020820.1XP_016876309.1  rho guanine nucleotide exchange factor 7 isoform X5

      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407490
      Atrophin-1; Atrophin-1 family
    10. XM_017020819.1XP_016876308.1  rho guanine nucleotide exchange factor 7 isoform X5

      Conserved Domains (6) summary
      cd12061
      Location:1063
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407490
      Atrophin-1; Atrophin-1 family
    11. XM_017020816.1XP_016876305.1  rho guanine nucleotide exchange factor 7 isoform X4

    12. XM_017020828.1XP_016876317.1  rho guanine nucleotide exchange factor 7 isoform X6

    13. XM_017020829.2XP_016876318.1  rho guanine nucleotide exchange factor 7 isoform X8

      Conserved Domains (4) summary
      cd00160
      Location:20147
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:178276
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:332430
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:283366
      Atrophin-1; Atrophin-1 family

    RNA

    1. XR_002957481.1 RNA Sequence

    2. XR_001749712.1 RNA Sequence

      Related
      ENST00000466143.5
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