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    FCGBP Fc gamma binding protein [ Homo sapiens (human) ]

    Gene ID: 8857, updated on 17-Jun-2024

    Summary

    Official Symbol
    FCGBPprovided by HGNC
    Official Full Name
    Fc gamma binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13572
    See related
    Ensembl:ENSG00000275395 MIM:617553; AllianceGenome:HGNC:13572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FC(GAMMA)BP
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Expression
    Biased expression in colon (RPKM 352.9), thyroid (RPKM 129.4) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FCGBP in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39863323..39934634, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42668261..42770240, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40353963..40440533, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10614 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1B Neighboring gene microRNA 6719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40335824-40336564 Neighboring gene fibrillarin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40357069-40358268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40376357-40376858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40433231-40433732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40449389-40449889 Neighboring gene Sharpr-MPRA regulatory region 5808 Neighboring gene proline rich 13 pseudogene 5 Neighboring gene uncharacterized LOC124904722 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:40465439-40466248

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    IgGFc-binding protein
    Names
    Fc fragment of IgG binding protein
    Human Fc gamma BP
    IgG Fc binding protein
    fcgamma-binding protein antigen
    fcgammaBP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003890.3NP_003881.2  IgGFc-binding protein precursor

      See identical proteins and their annotated locations for NP_003881.2

      Status: VALIDATED

      Source sequence(s)
      AC006950, AC007842, AC011536
      UniProtKB/Swiss-Prot
      O95784, Q9Y6R7
      Related
      ENSP00000481056.3, ENST00000616721.6
      Conserved Domains (5) summary
      smart00832
      Location:667742
      C8; This domain contains 8 conserved cysteine residues
      pfam00094
      Location:472627
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:23372390
      TIL; Trypsin Inhibitor like cysteine rich domain
      cl02516
      Location:52355382
      VWD; von Willebrand factor type D domain
      cl17735
      Location:11941245
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39863323..39934634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p14 PATCHES

      Range
      123199..225173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331644.1XP_054187619.1  IgGFc-binding protein isoform X1

      UniProtKB/Swiss-Prot
      O95784, Q9Y6R7
    2. XM_054331643.1XP_054187618.1  IgGFc-binding protein isoform X1

      UniProtKB/Swiss-Prot
      O95784, Q9Y6R7
    3. XM_054331645.1XP_054187620.1  IgGFc-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A087WXI2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42668261..42770240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322489.1XP_054178464.1  IgGFc-binding protein isoform X1

    2. XM_054322488.1XP_054178463.1  IgGFc-binding protein isoform X1