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    DLEU2 deleted in lymphocytic leukemia 2 [ Homo sapiens (human) ]

    Gene ID: 8847, updated on 7-Oct-2018

    Summary

    Official Symbol
    DLEU2provided by HGNC
    Official Full Name
    deleted in lymphocytic leukemia 2provided by HGNC
    Primary source
    HGNC:HGNC:13748
    See related
    Ensembl:ENSG00000231607 MIM:605766
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALT1; DLB2; LEU2; RFP2; BCMSUN; RFP2OS; MIR15AHG; TRIM13OS; LINC00022; NCRNA00022
    Summary
    This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]
    Expression
    Ubiquitous expression in bone marrow (RPKM 1.5), testis (RPKM 1.3) and 25 other tissues See more

    Genomic context

    See DLEU2 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (49982549..50125541, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50549491..50699680, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNY4 pseudogene 9 Neighboring gene SPRY domain containing 7 Neighboring gene microRNA 3613 Neighboring gene tripartite motif containing 13 Neighboring gene potassium channel regulator Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene deleted in lymphocytic leukemia 1 Neighboring gene ST13, Hsp70 interacting protein pseudogene 4 Neighboring gene ribosomal protein L34 pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • deleted in lymphocytic leukemia 2 (non-protein coding)
    • leukemia associated gene 2
    • long intergenic non-protein coding RNA 22
    • mir-15a-16-1 cluster host gene (non-protein coding)
    • ret finger protein 2 opposite strand

    Clone Names

    • MGC88287

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_152566.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AF529010, AY455757
      Related
      ENST00000621282.4
    2. NR_152567.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060
      Related
      ENST00000458725.5
    3. NR_152568.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060
    4. NR_152569.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC038090, BG611461
      Related
      ENST00000421758.5
    5. NR_152570.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060
      Related
      ENST00000449579.1
    6. NR_152571.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060
    7. NR_152572.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      49982549..50125541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_002612.1: Suppressed sequence

      Description
      NR_002612.1: This RefSeq was removed because currently there is not sufficient support for the transcript.
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