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    RGS9 regulator of G protein signaling 9 [ Homo sapiens (human) ]

    Gene ID: 8787, updated on 8-Jul-2021

    Summary

    Official Symbol
    RGS9provided by HGNC
    Official Full Name
    regulator of G protein signaling 9provided by HGNC
    Primary source
    HGNC:HGNC:10004
    See related
    Ensembl:ENSG00000108370 MIM:604067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PERRS; RGS9L
    Summary
    This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
    Expression
    Ubiquitous expression in brain (RPKM 1.6), lung (RPKM 1.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RGS9 in Genome Data Viewer
    Location:
    17q24.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (65137370..65227703)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (63133488..63223821)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371864 Neighboring gene uncharacterized LOC100507002 Neighboring gene VISTA enhancer hs1517 Neighboring gene zinc finger protein 848, pseudogene Neighboring gene long intergenic non-protein coding RNA 2563 Neighboring gene axin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC26458, MGC111763

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in dark adaptation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in light adaption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NMDA glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 9
    Names
    regulator of G-protein signalling 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013021.2 RefSeqGene

      Range
      5033..95366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001081955.3NP_001075424.1  regulator of G-protein signaling 9 isoform 2

      See identical proteins and their annotated locations for NP_001075424.1

      Status: REVIEWED

      Source sequence(s)
      AK290535, CK300804, DC322215
      Consensus CDS
      CCDS45764.1
      UniProtKB/Swiss-Prot
      O75916
      Related
      ENSP00000396329.3, ENST00000449996.7
      Conserved Domains (3) summary
      smart00224
      Location:221280
      GGL; G protein gamma subunit-like motifs
      cd08739
      Location:292412
      RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
      cd04450
      Location:22109
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    2. NM_001165933.2NP_001159405.1  regulator of G-protein signaling 9 isoform 3

      See identical proteins and their annotated locations for NP_001159405.1

      Status: REVIEWED

      Source sequence(s)
      AC015821, AC060771
      Related
      ENSP00000463410.1, ENST00000584234.5
      Conserved Domains (3) summary
      smart00224
      Location:221280
      GGL; G protein gamma subunit-like motifs
      cd08739
      Location:292412
      RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
      cd04450
      Location:22109
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    3. NM_003835.4NP_003826.2  regulator of G-protein signaling 9 isoform 1

      See identical proteins and their annotated locations for NP_003826.2

      Status: REVIEWED

      Source sequence(s)
      AF493933, AK289876, CK300804, DC322215
      Consensus CDS
      CCDS42373.1
      UniProtKB/Swiss-Prot
      O75916
      UniProtKB/TrEMBL
      A8K1G1
      Related
      ENSP00000262406.9, ENST00000262406.10
      Conserved Domains (3) summary
      smart00224
      Location:224283
      GGL; G protein gamma subunit-like motifs
      cd08739
      Location:295415
      RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
      cd04450
      Location:22109
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      65137370..65227703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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