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    RGS11 regulator of G protein signaling 11 [ Homo sapiens (human) ]

    Gene ID: 8786, updated on 5-Sep-2021

    Summary

    Official Symbol
    RGS11provided by HGNC
    Official Full Name
    regulator of G protein signaling 11provided by HGNC
    Primary source
    HGNC:HGNC:9993
    See related
    Ensembl:ENSG00000076344 MIM:603895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RS11
    Summary
    The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]
    Expression
    Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RGS11 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (268301..275944, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (318306..325944, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene LUC7 like Neighboring gene C4orf46 pseudogene 1 Neighboring gene family with sequence similarity 234 member A Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene protein disulfide isomerase family A member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of regulator of G-protein signaling 11 (RGS11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of G-protein signaling 11
    Names
    regulator of G-protein signalling 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286485.2NP_001273414.1  regulator of G-protein signaling 11 isoform 3

      See identical proteins and their annotated locations for NP_001273414.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of a coding exon and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB016929, AF035153, CK299324, DC423811, Z69667
      Consensus CDS
      CCDS66884.1
      UniProtKB/Swiss-Prot
      O94810
      Related
      ENSP00000352778.5, ENST00000359740.6
      Conserved Domains (3) summary
      smart00224
      Location:212273
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:284409
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:24107
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    2. NM_001286486.2NP_001273415.1  regulator of G-protein signaling 11 isoform 4

      See identical proteins and their annotated locations for NP_001273415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and lacks two alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AF035153, AK091701, CK299324, DC423811, Z69667
      UniProtKB/Swiss-Prot
      O94810
      Conserved Domains (2) summary
      smart00224
      Location:39100
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:111236
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
    3. NM_003834.3NP_003825.1  regulator of G-protein signaling 11 isoform 2

      See identical proteins and their annotated locations for NP_003825.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1. This results in translation initiation at a downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF035154, CK299324, DC423811, Z69667
      Consensus CDS
      CCDS10403.1
      UniProtKB/Swiss-Prot
      O94810
      Related
      ENSP00000319069.5, ENST00000316163.9
      Conserved Domains (3) summary
      smart00224
      Location:202263
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:274399
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:390
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    4. NM_183337.3NP_899180.1  regulator of G-protein signaling 11 isoform 1

      See identical proteins and their annotated locations for NP_899180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF035153, CK299324, DC423811, Z69667
      Consensus CDS
      CCDS42088.1
      UniProtKB/Swiss-Prot
      O94810
      UniProtKB/TrEMBL
      Q4TT70
      Related
      ENSP00000380876.3, ENST00000397770.8
      Conserved Domains (3) summary
      smart00224
      Location:223284
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:295420
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:24111
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      268301..275944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522719.2XP_011521021.1  regulator of G-protein signaling 11 isoform X1

      Conserved Domains (3) summary
      smart00224
      Location:255316
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:327452
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:24106
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    2. XM_011522720.2XP_011521022.1  regulator of G-protein signaling 11 isoform X2

      Conserved Domains (3) summary
      smart00224
      Location:234295
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:306431
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:385
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    3. XM_011522723.1XP_011521025.1  regulator of G-protein signaling 11 isoform X5

      See identical proteins and their annotated locations for XP_011521025.1

      UniProtKB/TrEMBL
      B7Z285
      Conserved Domains (1) summary
      cd04450
      Location:24111
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    4. XM_011522722.1XP_011521024.1  regulator of G-protein signaling 11 isoform X4

      Conserved Domains (1) summary
      cd04450
      Location:24106
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    5. XM_011522721.1XP_011521023.1  regulator of G-protein signaling 11 isoform X3

      Conserved Domains (1) summary
      cd04450
      Location:24106
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RNA

    1. XR_932957.2 RNA Sequence

      Related
      ENST00000168869.12
    2. XR_001752015.1 RNA Sequence

    3. XR_001752014.1 RNA Sequence

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