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    RGS11 regulator of G protein signaling 11 [ Homo sapiens (human) ]

    Gene ID: 8786, updated on 7-Dec-2018

    Summary

    Official Symbol
    RGS11provided by HGNC
    Official Full Name
    regulator of G protein signaling 11provided by HGNC
    Primary source
    HGNC:HGNC:9993
    See related
    Ensembl:ENSG00000076344 MIM:603895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RS11
    Summary
    The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]
    Expression
    Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues See more
    Orthologs

    Genomic context

    See RGS11 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (268301..275943, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (318300..325941, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene LUC7 like Neighboring gene chromosome 4 open reading frame 46 pseudogene Neighboring gene family with sequence similarity 234 member A Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene protein disulfide isomerase family A member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of regulator of G-protein signaling 11 (RGS11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
      Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
    • Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystem (from REACTOME)
      Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystemThe chaperonin complex TRiC/CCT is needed for the proper folding of all five G-protein beta subunits (Wells et al. 2006). TRiC/CCT cooperates with the phosducin-like protein PDCL (commonly known as P...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Protein folding, organism-specific biosystem (from REACTOME)
      Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein beta-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of G-protein signaling 11
    Names
    regulator of G-protein signalling 11

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286485.1NP_001273414.1  regulator of G-protein signaling 11 isoform 3

      See identical proteins and their annotated locations for NP_001273414.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of a coding exon and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB016929, AF035153, CK299324, DC423811
      Consensus CDS
      CCDS66884.1
      UniProtKB/Swiss-Prot
      O94810
      Related
      ENSP00000352778.5, ENST00000359740.6
      Conserved Domains (3) summary
      smart00224
      Location:212273
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:284409
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:24107
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    2. NM_001286486.1NP_001273415.1  regulator of G-protein signaling 11 isoform 4

      See identical proteins and their annotated locations for NP_001273415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and lacks two alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AF035153, AK091701, CK299324, DC423811, Z69667
      UniProtKB/Swiss-Prot
      O94810
      Conserved Domains (2) summary
      smart00224
      Location:39100
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:111236
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
    3. NM_003834.2NP_003825.1  regulator of G-protein signaling 11 isoform 2

      See identical proteins and their annotated locations for NP_003825.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1. This results in translation initiation at a downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF035154, CK299324, DC423811
      Consensus CDS
      CCDS10403.1
      UniProtKB/Swiss-Prot
      O94810
      Related
      ENSP00000319069.5, ENST00000316163.9
      Conserved Domains (3) summary
      smart00224
      Location:202263
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:274399
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:390
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    4. NM_183337.3NP_899180.1  regulator of G-protein signaling 11 isoform 1

      See identical proteins and their annotated locations for NP_899180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF035153, CK299324, DC423811, Z69667
      Consensus CDS
      CCDS42088.1
      UniProtKB/Swiss-Prot
      O94810
      UniProtKB/TrEMBL
      Q4TT70
      Related
      ENSP00000380876.3, ENST00000397770.7
      Conserved Domains (3) summary
      smart00224
      Location:223284
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:295420
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:24111
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      268301..275943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522719.2XP_011521021.1  regulator of G-protein signaling 11 isoform X1

      Conserved Domains (3) summary
      smart00224
      Location:255316
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:327452
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:24106
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    2. XM_011522720.2XP_011521022.1  regulator of G-protein signaling 11 isoform X2

      Conserved Domains (3) summary
      smart00224
      Location:234295
      GGL; G protein gamma subunit-like motifs
      cd08740
      Location:306431
      RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
      cd04450
      Location:385
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    3. XM_011522723.1XP_011521025.1  regulator of G-protein signaling 11 isoform X5

      See identical proteins and their annotated locations for XP_011521025.1

      UniProtKB/TrEMBL
      B7Z285
      Conserved Domains (1) summary
      cd04450
      Location:24111
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    4. XM_011522722.1XP_011521024.1  regulator of G-protein signaling 11 isoform X4

      Conserved Domains (1) summary
      cd04450
      Location:24106
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    5. XM_011522721.1XP_011521023.1  regulator of G-protein signaling 11 isoform X3

      Conserved Domains (1) summary
      cd04450
      Location:24106
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RNA

    1. XR_932957.2 RNA Sequence

      Related
      ENST00000168869.12
    2. XR_001752015.1 RNA Sequence

    3. XR_001752014.1 RNA Sequence

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