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    TNFSF14 TNF superfamily member 14 [ Homo sapiens (human) ]

    Gene ID: 8740, updated on 29-Mar-2023

    Summary

    Official Symbol
    TNFSF14provided by HGNC
    Official Full Name
    TNF superfamily member 14provided by HGNC
    Primary source
    HGNC:HGNC:11930
    See related
    Ensembl:ENSG00000125735 MIM:604520; AllianceGenome:HGNC:11930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LTg; CD258; HVEML; LIGHT
    Summary
    The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in liver (RPKM 1.5), appendix (RPKM 0.9) and 18 other tissues See more
    Orthologs
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    Genomic context

    See TNFSF14 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6661253..6670588, complement)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6650888..6660217, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6661264..6670599, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 50 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6631163-6631664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6674384-6674960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6674961-6675535

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Expression of HIV-1 Nef in a CD4+ human T-cell hybridoma enhances the surface levels of the membrane-bound cytokines tumor necrosis factor (TNF) and LIGHT; the enhancement of TNF and LIGHT depends on the presence of a functional dileucine motif in Nef PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in T cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell homeostasis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in T cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NIK/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 14
    Names
    herpesvirus entry mediator ligand
    tumor necrosis factor (ligand) superfamily, member 14
    tumor necrosis factor ligand 1D
    tumor necrosis factor superfamily member 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376887.1NP_001363816.1  tumor necrosis factor ligand superfamily member 14 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008760, AF064090, BC018058
      Consensus CDS
      CCDS12171.1
      UniProtKB/Swiss-Prot
      Q96LD2
      Related
      ENSP00000502837.1, ENST00000675206.1
      Conserved Domains (1) summary
      cd00184
      Location:94238
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    2. NM_003807.5NP_003798.2  tumor necrosis factor ligand superfamily member 14 isoform 1

      See identical proteins and their annotated locations for NP_003798.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC008760, AF064090, AK026704, AY358812
      Consensus CDS
      CCDS12171.1
      UniProtKB/Swiss-Prot
      O43557, Q96LD2
      Related
      ENSP00000469049.1, ENST00000599359.1
      Conserved Domains (1) summary
      cd00184
      Location:94238
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    3. NM_172014.3NP_742011.2  tumor necrosis factor ligand superfamily member 14 isoform 2

      See identical proteins and their annotated locations for NP_742011.2

      Status: REVIEWED

      Source sequence(s)
      AC008760, AF064090, AK026704, AY028261
      Consensus CDS
      CCDS45939.1
      UniProtKB/Swiss-Prot
      O43557
      Related
      ENSP00000245912.3, ENST00000245912.7
      Conserved Domains (1) summary
      cd00184
      Location:58202
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      6661253..6670588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      6650888..6660217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)