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    S1PR4 sphingosine-1-phosphate receptor 4 [ Homo sapiens (human) ]

    Gene ID: 8698, updated on 1-Aug-2020

    Summary

    Official Symbol
    S1PR4provided by HGNC
    Official Full Name
    sphingosine-1-phosphate receptor 4provided by HGNC
    Primary source
    HGNC:HGNC:3170
    See related
    Ensembl:ENSG00000125910 MIM:603751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDG6; LPC1; S1P4; SLP4
    Summary
    This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See S1PR4 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3178769..3180332)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3178250..3180335)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996351 Neighboring gene G protein subunit alpha 15 Neighboring gene Sharpr-MPRA regulatory region 13242 Neighboring gene nicalin Neighboring gene CUGBP Elav-like family member 5 Neighboring gene uncharacterized LOC105372244

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sphingosine-1-phosphate receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    activation of phospholipase C activity TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 4
    Names
    S1P receptor 4
    S1P receptor Edg-6
    endothelial differentiation G-protein coupled receptor 6
    endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
    sphingosine 1-phosphate receptor Edg-6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003775.4NP_003766.1  sphingosine 1-phosphate receptor 4 precursor

      See identical proteins and their annotated locations for NP_003766.1

      Status: REVIEWED

      Source sequence(s)
      BC014970
      Consensus CDS
      CCDS12105.1
      UniProtKB/Swiss-Prot
      O95977
      Related
      ENSP00000246115.3, ENST00000246115.5
      Conserved Domains (2) summary
      cd14964
      Location:4973
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:47318
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      3178769..3180332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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