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    RGS20 regulator of G protein signaling 20 [ Homo sapiens (human) ]

    Gene ID: 8601, updated on 7-Dec-2018

    Summary

    Official Symbol
    RGS20provided by HGNC
    Official Full Name
    regulator of G protein signaling 20provided by HGNC
    Primary source
    HGNC:HGNC:14600
    See related
    Ensembl:ENSG00000147509 MIM:607193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGSZ1; ZGAP1; gz-GAP; g(z)GAP
    Summary
    The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Expression
    Biased expression in brain (RPKM 2.5), thyroid (RPKM 0.6) and 3 other tissues See more
    Orthologs

    Genomic context

    See RGS20 in Genome Data Viewer
    Location:
    8q11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (53851808..53959304)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54764368..54871863)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 13 pseudogene Neighboring gene ATPase H+ transporting V1 subunit H Neighboring gene ribosomal protein S27a pseudogene 13 Neighboring gene RNA, U6 small nuclear 1331, pseudogene Neighboring gene Sharpr-MPRA regulatory region 792/14152 Neighboring gene ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) pseudogene Neighboring gene transcription elongation factor A1 Neighboring gene uncharacterized LOC105375839

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of G-protein signaling 20
    Names
    gz-selective GTPase-activating protein
    regulator of G-protein signaling 20 variant 2
    regulator of G-protein signaling Z1
    regulator of G-protein signalling 20
    regulator of Gz-selective protein signaling 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286673.1NP_001273602.1  regulator of G-protein signaling 20 isoform c

      See identical proteins and their annotated locations for NP_001273602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region comapred to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC100821, AC113194, AF366054
      Consensus CDS
      CCDS69482.1
      UniProtKB/Swiss-Prot
      O76081
      Related
      ENSP00000344630.6, ENST00000344277.10
      Conserved Domains (1) summary
      cd08746
      Location:106261
      RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein
    2. NM_001286674.1NP_001273603.1  regulator of G-protein signaling 20 isoform d

      See identical proteins and their annotated locations for NP_001273603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three in-frame exons in the central coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC100821, AC113194, AF366056
      UniProtKB/Swiss-Prot
      O76081
      Conserved Domains (1) summary
      cl02565
      Location:12140
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_001286675.1NP_001273604.1  regulator of G-protein signaling 20 isoform e

      See identical proteins and their annotated locations for NP_001273604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AC100821, AC113194, AF366055
      UniProtKB/Swiss-Prot
      O76081
      Conserved Domains (1) summary
      cl02565
      Location:11168
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    4. NM_003702.4NP_003693.2  regulator of G-protein signaling 20 isoform b

      See identical proteins and their annotated locations for NP_003693.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC100821, AK094503, BC063490
      Consensus CDS
      CCDS6156.1
      UniProtKB/Swiss-Prot
      O76081
      UniProtKB/TrEMBL
      B3KSW4, H9NIM5
      Related
      ENSP00000276500.4, ENST00000276500.4
      Conserved Domains (1) summary
      cd08746
      Location:74229
      RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein
    5. NM_170587.4NP_733466.1  regulator of G-protein signaling 20 isoform a

      See identical proteins and their annotated locations for NP_733466.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC100821, AC113194, AY046538
      Consensus CDS
      CCDS6155.1
      UniProtKB/Swiss-Prot
      O76081
      Related
      ENSP00000297313.3, ENST00000297313.7
      Conserved Domains (1) summary
      cd08746
      Location:221376
      RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein

    RNA

    1. NR_104578.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate exon structure compared to variant 1 but does share exon structure with variant 2. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC113194, BC054867
      Related
      ENST00000523064.1
    2. NR_104579.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC100821, AC113194, AK094503
      Related
      ENST00000522225.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      53851808..53959304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517622.3XP_011515924.1  regulator of G-protein signaling 20 isoform X1

      See identical proteins and their annotated locations for XP_011515924.1

      UniProtKB/Swiss-Prot
      O76081
      Conserved Domains (1) summary
      cd08746
      Location:50205
      RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein
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