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    BMH1 14-3-3 family protein BMH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856924, updated on 17-May-2024

    Summary

    Gene symbol
    BMH1
    Gene description
    14-3-3 family protein BMH1
    Primary source
    FungiDB:YER177W
    Locus tag
    YER177W
    See related
    SGD:S000000979; AllianceGenome:SGD:S000000979; VEuPathDB:YER177W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APR6
    Summary
    Enables DNA replication origin binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and phosphoserine residue binding activity. Involved in several processes, including aggresome assembly; intracellular signal transduction; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 56; transitional cell carcinoma; and vulva squamous cell carcinoma. Orthologous to several human genes including YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See BMH1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (545611..546414)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA helicase Neighboring gene pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha Neighboring gene recombinase DMC1

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in aggresome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ascospore formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in fungal-type cell wall chitin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mitotic cell cycle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in mitotic spindle orientation checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of glycogen metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction involved in filamentous growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    14-3-3 family protein BMH1
    NP_011104.3
    • 14-3-3 protein, major isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome formation, the spindle position checkpoint and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; antiapoptotic gene; similar to several human 14-3-3 proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      545611..546414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179067.3NP_011104.3  TPA: 14-3-3 family protein BMH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011104.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM86, P29311, Q06854
      UniProtKB/TrEMBL
      A0A6A5PXL2, A6ZRD4, B3LRT7, B5VHV9, C7GS32, C8Z7K1, N1P3Q2
      Conserved Domains (1) summary
      COG5040
      Location:1267
      BMH1; 14-3-3 family protein [Signal transduction mechanisms]