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    PTP3 tyrosine protein phosphatase PTP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856807, updated on 17-May-2024

    Summary

    Gene symbol
    PTP3
    Gene description
    tyrosine protein phosphatase PTP3
    Primary source
    FungiDB:YER075C
    Locus tag
    YER075C
    See related
    SGD:S000000877; AllianceGenome:SGD:S000000877; VEuPathDB:YER075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of cell wall integrity MAPK cascade; peptidyl-tyrosine dephosphorylation; and pheromone response MAPK cascade. Located in cytoplasm and nucleus. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See PTP3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (308413..311199, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S24A Neighboring gene Yos1p Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine protein phosphatase PTP3
    NP_010998.2
    • Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      308413..311199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178966.2NP_010998.2  TPA: tyrosine protein phosphatase PTP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010998.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLY1, P40048
      UniProtKB/TrEMBL
      A0A8H8ULU1, B3LRJ2, C7GRQ7, C8Z784
      Conserved Domains (2) summary
      cd01446
      Location:97231
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd18533
      Location:571873
      PTP_fungal; fungal protein tyrosine phosphatases