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    PHO12 acid phosphatase PHO12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856625, updated on 17-May-2024

    Summary

    Gene symbol
    PHO12
    Gene description
    acid phosphatase PHO12
    Primary source
    FungiDB:YHR215W
    Locus tag
    YHR215W
    See related
    SGD:S000001258; AllianceGenome:SGD:S000001258; VEuPathDB:YHR215W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PHO10
    Summary
    Enables acid phosphatase activity. Predicted to be involved in dephosphorylation. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia and thyroid gland papillary carcinoma. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See PHO12 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (552099..553502)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene IMP dehydrogenase IMD2 Neighboring gene uncharacterized protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in fungal-type vacuole HDA PubMed 

    General protein information

    Preferred Names
    acid phosphatase PHO12
    NP_012087.1
    • One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      552099..553502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179346.1NP_012087.1  TPA: acid phosphatase PHO12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012087.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLH0, P38693
      UniProtKB/TrEMBL
      A0A8H4C1M3, A6ZSK5, B3LUF9, B5VKE4, C7GJR1, C8Z7M5, N1P2L2
      Conserved Domains (1) summary
      pfam00328
      Location:65399
      His_Phos_2; Histidine phosphatase superfamily (branch 2)