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    TCO89 Tco89p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855922, updated on 17-May-2024

    Summary

    Gene symbol
    TCO89
    Gene description
    Tco89p
    Primary source
    FungiDB:YPL180W
    Locus tag
    YPL180W
    See related
    SGD:S000006101; AllianceGenome:SGD:S000006101; VEuPathDB:YPL180W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including fungal-type cell wall organization; glycerol metabolic process; and response to salt stress. Located in fungal-type vacuole membrane. Is extrinsic component of cytoplasmic side of plasma membrane and extrinsic component of vacuolar membrane. Part of TORC1 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See TCO89 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (205248..207647)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rtt10p Neighboring gene Cti6p Neighboring gene protein-serine/threonine phosphatase Neighboring gene tRNA-Glu

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TORC1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of TORC1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Tco89p
    NP_015145.1
    • Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      205248..207647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183994.1NP_015145.1  TPA: Tco89p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I8, Q08921
      UniProtKB/TrEMBL
      A0A8H4BTZ6, A6ZW73, B3LKP8, B5VSZ2, C7GJC9, N1P2P2
      Conserved Domains (1) summary
      pfam10452
      Location:30732
      TCO89; TORC1 subunit TCO89