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    CLN2 cyclin CLN2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855819, updated on 17-May-2024

    Summary

    Gene symbol
    CLN2
    Gene description
    cyclin CLN2
    Primary source
    FungiDB:YPL256C
    Locus tag
    YPL256C
    See related
    SGD:S000006177; AllianceGenome:SGD:S000006177; VEuPathDB:YPL256C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in re-entry into mitotic cell cycle after pheromone arrest; regulation of cyclin-dependent protein serine/threonine kinase activity; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 29 and prostate cancer. Orthologous to several human genes including CCNA1 (cyclin A1); CCNA2 (cyclin A2); and CCNJ (cyclin J). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See CLN2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (64977..66614, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene uncharacterized protein Neighboring gene Bbp1p Neighboring gene Hfi1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cyclin CLN2
    NP_015067.1
    • G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      64977..66614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184070.1NP_015067.1  TPA: cyclin CLN2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3B5, E9P938, P20438
      UniProtKB/TrEMBL
      A0A8H4BTJ1, B3LKH6, B5VST1, C7GTR3, C8ZIC2, N1P1M4
      Conserved Domains (1) summary
      COG5024
      Location:33524
      COG5024; Cyclin [Cell division and chromosome partitioning]