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    CLN1 cyclin CLN1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855239, updated on 17-May-2024

    Summary

    Gene symbol
    CLN1
    Gene description
    cyclin CLN1
    Primary source
    FungiDB:YMR199W
    Locus tag
    YMR199W
    See related
    SGD:S000004812; AllianceGenome:SGD:S000004812; VEuPathDB:YMR199W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of cyclin-dependent protein serine/threonine kinase activity and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 29 and prostate cancer. Orthologous to several human genes including CCNA1 (cyclin A1); CCNA2 (cyclin A2); and CCNJ (cyclin J). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See CLN1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (662644..664284)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene v-SNARE protein VTI1 Neighboring gene Cik1p Neighboring gene Rot1p Neighboring gene DNA repair protein RAD14

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cyclin CLN1
    NP_013926.1
    • G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      662644..664284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182706.1NP_013926.1  TPA: cyclin CLN1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013926.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W024, P20437
      UniProtKB/TrEMBL
      A0A8H4BWJ3, A6ZMR1, B3LM87, B5VPW8, C7GRF2, N1NYY9
      Conserved Domains (1) summary
      COG5024
      Location:31539
      COG5024; Cyclin [Cell division and chromosome partitioning]