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    CMP2 calcineurin catalytic subunit A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854946, updated on 19-Jun-2024

    Summary

    Gene symbol
    CMP2
    Gene description
    calcineurin catalytic subunit A
    Primary source
    FungiDB:YML057W
    Locus tag
    YML057W
    See related
    SGD:S000004521; AllianceGenome:SGD:S000004521; VEuPathDB:YML057W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CNA2
    Summary
    Contributes to calcium-dependent protein serine/threonine phosphatase activity. Involved in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion and cellular ion homeostasis. Located in cytoplasm. Part of calcineurin complex. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PPP3CB (protein phosphatase 3 catalytic subunit beta); and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See CMP2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (160180..161994)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Hug1p Neighboring gene ribonucleotide reductase inhibiting protein SML1 Neighboring gene IMP dehydrogenase IMD4 Neighboring gene ncRNA Neighboring gene signal peptidase complex subunit SPC2

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to calcium-dependent protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of calcineurin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    calcineurin catalytic subunit A
    NP_013655.1
    • Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      160180..161994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182415.1NP_013655.1  TPA: calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZB7, P14747
      UniProtKB/TrEMBL
      A0A8H4BYA8, A6ZM09, B3LLJ9, G2WJZ9, N1NZ01
      Conserved Domains (1) summary
      cd07416
      Location:95423
      MPP_PP2B; PP2B, metallophosphatase domain