U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PAN1 Pan1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854822, updated on 17-May-2024

    Summary

    Gene symbol
    PAN1
    Gene description
    Pan1p
    Primary source
    FungiDB:YIR006C
    Locus tag
    YIR006C
    See related
    SGD:S000001445; AllianceGenome:SGD:S000001445; VEuPathDB:YIR006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DIM2; MDP3; MIP3
    Summary
    Enables Arp2/3 complex binding activity. Involved in several processes, including actin cortical patch assembly; cellular bud site selection; and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch and nucleus. Part of actin cytoskeleton-regulatory complex. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to several human genes including REPS1 (RALBP1 associated Eps domain containing 1); REPS2 (RALBP1 associated Eps domain containing 2); and EPS15 (epidermal growth factor receptor pathway substrate 15). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAN1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (365466..369908, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Djp1p Neighboring gene U2 snRNP complex subunit IST3 Neighboring gene tRNA-Glu Neighboring gene hydrolase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cortical patch assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within reticulophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
     
    part_of actin cytoskeleton-regulatory complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of actin cytoskeleton-regulatory complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cellular bud neck HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mating projection tip HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Pan1p
    NP_012271.3
    • Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; regulates late stages of endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      365466..369908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179528.3NP_012271.3  TPA: Pan1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012271.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVT6, P32521
      UniProtKB/TrEMBL
      A0A8H4C1N5, C7GJG6, N1P975
      Conserved Domains (4) summary
      smart00027
      Location:595688
      EH; Eps15 homology domain
      pfam08226
      Location:459553
      DUF1720; Domain of unknown function (DUF1720)
      NF012221
      Location:8841033
      MARTX_Nterm; MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region
      pfam02948
      Location:10561125
      Amelogenin