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    KIN4 putative serine/threonine protein kinase KIN4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854408, updated on 17-May-2024

    Summary

    Gene symbol
    KIN4
    Gene description
    putative serine/threonine protein kinase KIN4
    Primary source
    FungiDB:YOR233W
    Locus tag
    YOR233W
    See related
    SGD:S000005759; AllianceGenome:SGD:S000005759; VEuPathDB:YOR233W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KIN3; KIN31
    Summary
    Enables protein serine/threonine kinase activity. Involved in mitotic spindle orientation checkpoint signaling and protein localization to spindle pole body. Located in cell cortex; cellular bud neck; and spindle pole body. Orthologous to human HUNK (hormonally up-regulated Neu-associated kinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See KIN4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (775846..778248)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase MKK1 Neighboring gene Mge1p Neighboring gene ribosomal 60S subunit protein L33B Neighboring gene Irc13p Neighboring gene ncRNA

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity HDA PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative serine/threonine protein kinase KIN4
    NP_014876.1
    • Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint (SPOC) is activated; regulates peroxisomal transport and vacuolar inheritance along with Frk1p; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Frk1p; localizes asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      775846..778248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183652.1NP_014876.1  TPA: putative serine/threonine protein kinase KIN4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014876.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2T7, Q01919
      UniProtKB/TrEMBL
      A0A6V8RZL7, A6ZP74, B3LJQ5, B5VSB4, C7GWF1, C8ZGY7, N1NWU2
      Conserved Domains (1) summary
      cd14076
      Location:44313
      STKc_Kin4; Catalytic domain of the yeast Serine/Threonine Kinase, Kin4