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    PTP2 tyrosine protein phosphatase PTP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854383, updated on 17-May-2024

    Summary

    Gene symbol
    PTP2
    Gene description
    tyrosine protein phosphatase PTP2
    Primary source
    FungiDB:YOR208W
    Locus tag
    YOR208W
    See related
    SGD:S000005734; AllianceGenome:SGD:S000005734; VEuPathDB:YOR208W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of cell wall integrity MAPK cascade; peptidyl-tyrosine dephosphorylation; and response to pheromone triggering conjugation with cellular fusion. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See PTP2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (733925..736177)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mRNA-binding ribosome synthesis protein NOC2 Neighboring gene DNA-directed RNA polymerase III core subunit RET1 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene DNA-directed RNA polymerase core subunit RPB10

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine protein phosphatase PTP2
    NP_014851.3
    • Phosphotyrosine-specific phosphatase; major role in osmolarity sensing through dephosphorylation of the Hog1p MAPK with a minor role by Ptp3p; inactivates and regulates Hog1p localization; major role in the cell wall integrity pathway through dephosphorylation of MAPK Slt2p with a minor role by Ptp3p; minor role with Msg5p in the pheromone adaptive response through dephosphorylation of MAPK Fus3p with major role by Ptp3p; co-regulates the calcium signaling pathway with Msg5p; nuclear localized

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      733925..736177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183627.3NP_014851.3  TPA: tyrosine protein phosphatase PTP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014851.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2R4, P29461
      UniProtKB/TrEMBL
      A0A8H4BWD0, N1NYM7
      Conserved Domains (1) summary
      COG5599
      Location:344748
      COG5599; Protein tyrosine phosphatase [Signal transduction mechanisms]