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    SKM1 putative serine/threonine protein kinase SKM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854036, updated on 17-May-2024

    Summary

    Gene symbol
    SKM1
    Gene description
    putative serine/threonine protein kinase SKM1
    Primary source
    FungiDB:YOL113W
    Locus tag
    YOL113W
    See related
    SGD:S000005473; AllianceGenome:SGD:S000005473; VEuPathDB:YOL113W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in negative regulation of macromolecule metabolic process; septum digestion after cytokinesis; and sterol import. Located in nucleus and plasma membrane. Human ortholog(s) of this gene implicated in breast cancer; non-syndromic X-linked intellectual disability 30; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PAK3 (p21 (RAC1) activated kinase 3); and PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See SKM1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (104326..106293)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene non-canonical poly(A) polymerase PAP2 Neighboring gene Pth4p Neighboring gene Rab GTPase-activating protein MSB4 Neighboring gene Mdy2p

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity HDA PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of sterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative serine/threonine protein kinase SKM1
    NP_014528.1
    • Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      104326..106293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183367.1NP_014528.1  TPA: putative serine/threonine protein kinase SKM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1V4, E9P934, Q06940, Q12469
      UniProtKB/TrEMBL
      A0A8H4BUG6, G2WMC3, N1NW98
      Conserved Domains (3) summary
      cd13279
      Location:4113
      PH_Cla4_Ste20; Pleckstrin homology (PH) domain
      cd06614
      Location:359640
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
      pfam00786
      Location:122180
      PBD; P21-Rho-binding domain