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    RGS8 regulator of G protein signaling 8 [ Homo sapiens (human) ]

    Gene ID: 85397, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RGS8provided by HGNC
    Official Full Name
    regulator of G protein signaling 8provided by HGNC
    Primary source
    HGNC:HGNC:16810
    See related
    Ensembl:ENSG00000135824 MIM:607189; AllianceGenome:HGNC:16810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q25.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (182641818..182752376, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (182001318..182111553, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182610953..182721511, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182584000-182584897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182584926-182585474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182585475-182586022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2205 Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene regulator of G protein signaling 16 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:182612621-182613820 Neighboring gene long intergenic non-protein coding RNA 1688 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182711495-182712108 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:182729835-182731034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182758561-182759061 Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2208 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182808107-182808948 Neighboring gene DHX9 antisense RNA 1 Neighboring gene DExH-box helicase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics. Benians A, et al. J Biol Chem, 2005 Apr 8. PMID 15677457
    2. Participation of RGS8 in the ternary complex of agonist, receptor and G-protein. Benians A, et al. Biochem Soc Trans, 2004 Dec. PMID 15506959
    3. Biochemical and electrophysiological analyses of RGS8 function. Saitoh O, et al. Methods Enzymol, 2004. PMID 15488175
    4. The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression. Masuho I, et al. J Neurochem, 2004 Jan. PMID 14675160
    5. Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain. Song D, et al. J Recept Signal Transduct Res, 2016 Oct. PMID 26754208

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets.
      Title: Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets.
    2. The chimeric RGS8 domains containing the first or the second exon part of RGS5 showed strong inhibitory effects similar to that of wild type RGS8, but the chimeric domain with the third exon part of RGS5 lost its activity
      Title: Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
    3. Missense mutations in RGS8 gene is associated with breast cancer.
      Title: High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Spinophilin was identified as an RGS8-interacting protein.
      Title: Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.
    7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Association of RGS2 and RGS5 variants with schizophrenia symptom severity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119067, MGC119068, MGC119069

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 8
    Names
    regulator of G-protein signalling 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102450.3 → NP_001095920.1  regulator of G-protein signaling 8 isoform 2

      See identical proteins and their annotated locations for NP_001095920.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region, which results in an alternate 5' coding sequence, as compared to variant 1. The resulting isoform (2) has a shorter and alternate N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL353778
      Consensus CDS
      CCDS41443.1
      UniProtKB/Swiss-Prot
      B4DGL9, P57771, Q3SYD2
      Related
      ENSP00000511884.1, ENST00000515211.2
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    2. NM_001369564.2 → NP_001356493.1  regulator of G-protein signaling 8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL353778
      Consensus CDS
      CCDS41443.1
      UniProtKB/Swiss-Prot
      B4DGL9, P57771, Q3SYD2
      Related
      ENSP00000356527.1, ENST00000367556.5
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    3. NM_001387847.1 → NP_001374776.1  regulator of G-protein signaling 8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL353778, AL513344
      Consensus CDS
      CCDS41443.1
      UniProtKB/Swiss-Prot
      B4DGL9, P57771, Q3SYD2
      Related
      ENSP00000356528.4, ENST00000367557.8
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    4. NM_001387848.1 → NP_001374777.1  regulator of G-protein signaling 8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL353778
      Consensus CDS
      CCDS41443.1
      UniProtKB/Swiss-Prot
      B4DGL9, P57771, Q3SYD2
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    5. NM_001387849.1 → NP_001374778.1  regulator of G-protein signaling 8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK296514, AL353778
      Consensus CDS
      CCDS41443.1
      UniProtKB/Swiss-Prot
      B4DGL9, P57771, Q3SYD2
      Related
      ENSP00000426289.1, ENST00000483095.6
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    6. NM_033345.4 → NP_203131.1  regulator of G-protein signaling 8 isoform 1

      See identical proteins and their annotated locations for NP_203131.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL353778
      Consensus CDS
      CCDS1349.1
      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:64 → 188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      182641818..182752376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510089.4 → XP_011508391.1  regulator of G-protein signaling 8 isoform X1

      See identical proteins and their annotated locations for XP_011508391.1

      UniProtKB/Swiss-Prot
      P57771
      Related
      ENSP00000258302.4, ENST00000258302.8
      Conserved Domains (1) summary
      cd08711
      Location:64 → 188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    2. XM_017002631.3 → XP_016858120.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:64 → 188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    3. XM_047432939.1 → XP_047288895.1  regulator of G-protein signaling 8 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      182001318..182111553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339321.1 → XP_054195296.1  regulator of G-protein signaling 8 isoform X1

    2. XM_054339320.1 → XP_054195295.1  regulator of G-protein signaling 8 isoform X1

    3. XM_054339319.1 → XP_054195294.1  regulator of G-protein signaling 8 isoform X1

    4. XM_054339318.1 → XP_054195293.1  regulator of G-protein signaling 8 isoform X1

    5. XM_054339322.1 → XP_054195297.1  regulator of G-protein signaling 8 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57771.1 GenPept UniProtKB/Swiss-Prot:P57771

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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