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    RGS8 regulator of G protein signaling 8 [ Homo sapiens (human) ]

    Gene ID: 85397, updated on 18-Sep-2018

    Summary

    Official Symbol
    RGS8provided by HGNC
    Official Full Name
    regulator of G protein signaling 8provided by HGNC
    Primary source
    HGNC:HGNC:16810
    See related
    Ensembl:ENSG00000135824 MIM:607189; Vega:OTTHUMG00000035219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues See more
    Orthologs

    Genomic context

    See RGS8 in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (182641814..182753293, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182613036..182653502, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 16 Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene long intergenic non-protein coding RNA 1688 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component pseudogene Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene uncharacterized LOC647070 Neighboring gene DExH-box helicase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC119067, MGC119068, MGC119069

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 8
    Names
    regulator of G-protein signalling 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102450.2NP_001095920.1  regulator of G-protein signaling 8 isoform 2

      See identical proteins and their annotated locations for NP_001095920.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region, which results in an alternate 5' coding sequence, as compared to variant 1. The resulting isoform (2) has a shorter and alternate N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK057753, AL353778, BC103867, BG195915, BM681011, R37101
      Consensus CDS
      CCDS41443.1
      UniProtKB/Swiss-Prot
      P57771
      Related
      ENSP00000356528.4, OTTHUMP00000217395, ENST00000367557.8, OTTHUMT00000358978
      Conserved Domains (1) summary
      cd08711
      Location:46170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    2. NM_033345.3NP_203131.1  regulator of G-protein signaling 8 isoform 1

      See identical proteins and their annotated locations for NP_203131.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI209102, AK057753, AL353778, BC069677, BG195915, BM681011, BX954018, R37101
      Consensus CDS
      CCDS1349.1
      UniProtKB/Swiss-Prot
      P57771
      Related
      ENSP00000258302.4, OTTHUMP00000217398, ENST00000258302.8, OTTHUMT00000085202
      Conserved Domains (1) summary
      cd08711
      Location:64188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      182641814..182753293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510089.3XP_011508391.1  regulator of G-protein signaling 8 isoform X1

      See identical proteins and their annotated locations for XP_011508391.1

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:64188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    2. XM_017002634.1XP_016858123.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:64188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    3. XM_017002632.1XP_016858121.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:64188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    4. XM_017002631.2XP_016858120.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:64188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    5. XM_017002633.1XP_016858122.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:64188
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    6. XM_017002635.1XP_016858124.1  regulator of G-protein signaling 8 isoform X2

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:46170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    7. XM_011510090.2XP_011508392.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_011508392.1

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:46170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    8. XM_017002637.2XP_016858126.1  regulator of G-protein signaling 8 isoform X2

      UniProtKB/Swiss-Prot
      P57771
      Conserved Domains (1) summary
      cd08711
      Location:46170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    9. XM_011510091.3XP_011508393.1  regulator of G-protein signaling 8 isoform X3

      See identical proteins and their annotated locations for XP_011508393.1

      Conserved Domains (1) summary
      cd08711
      Location:44168
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    10. XM_005245555.4XP_005245612.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_005245612.1

      UniProtKB/Swiss-Prot
      P57771
      Related
      ENSP00000426289.1, OTTHUMP00000217396, ENST00000483095.6
      Conserved Domains (1) summary
      cd08711
      Location:46170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
    11. XM_017002636.2XP_016858125.1  regulator of G-protein signaling 8 isoform X2

      UniProtKB/Swiss-Prot
      P57771
      Related
      ENSP00000356527.1, OTTHUMP00000033156, ENST00000367556.5
      Conserved Domains (1) summary
      cd08711
      Location:46170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
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