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    PBS2 mitogen-activated protein kinase kinase PBS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853313, updated on 17-May-2024

    Summary

    Gene symbol
    PBS2
    Gene description
    mitogen-activated protein kinase kinase PBS2
    Primary source
    FungiDB:YJL128C
    Locus tag
    YJL128C
    See related
    SGD:S000003664; AllianceGenome:SGD:S000003664; VEuPathDB:YJL128C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HOG4; SFS4; SSK4
    Summary
    Enables MAP kinase kinase activity and MAP-kinase scaffold activity. Involved in several processes, including actin filament organization; cellular response to osmotic stress; and protein import into nucleus. Located in cellular bud neck; cellular bud tip; and cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Pick's disease; female reproductive organ cancer (multiple); progressive supranuclear palsy; respiratory system cancer (multiple); and restrictive cardiomyopathy. Orthologous to several human genes including MAP2K4 (mitogen-activated protein kinase kinase 4); MAP2K6 (mitogen-activated protein kinase kinase 6); and MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See PBS2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (178097..180103, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase Neighboring gene Trk1p Neighboring gene Mco6p Neighboring gene Spt10p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular hyperosmotic response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular hyperosmotic response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in osmosensory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in p38MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic stress granule HDA PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase PBS2
    NP_012407.2
    • MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      178097..180103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181561.2NP_012407.2  TPA: mitogen-activated protein kinase kinase PBS2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012407.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW57, P08018
      UniProtKB/TrEMBL
      A0A8H4BYD7, B3LPZ0, C7GQ00, C8ZB89, N1P936
      Conserved Domains (1) summary
      cd06622
      Location:358644
      PKc_PBS2_like; Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases