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    PPT1 protein serine/threonine phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853023, updated on 18-Sep-2024

    Summary

    Official Symbol
    PPT1
    Official Full Name
    protein serine/threonine phosphatase
    Primary source
    SGD:S000003355
    Locus tag
    YGR123C
    See related
    AllianceGenome:SGD:S000003355; FungiDB:YGR123C; VEuPathDB:YGR123C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in cytoplasm and nucleus. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See PPT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (736662..738203, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Arg Neighboring gene tRNA-Ile Neighboring gene asparagine synthase (glutamine-hydrolyzing) 2

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein serine/threonine phosphatase
    NP_011639.3
    • Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      736662..738203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181252.3NP_011639.3  TPA: protein serine/threonine phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011639.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ5, P53043
      UniProtKB/TrEMBL
      A6ZUD7, B3LIA5, B5VJ69, C7GUH2, C8Z916, N1P3Q7
      Conserved Domains (3) summary
      PLN03088
      Location:10130
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:1240
      TPR; TPR repeat [structural motif]
      cd07417
      Location:165508
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain