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    ALK1 protein kinase ALK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852863, updated on 17-May-2024

    Summary

    Gene symbol
    ALK1
    Gene description
    protein kinase ALK1
    Primary source
    FungiDB:YGL021W
    Locus tag
    YGL021W
    See related
    SGD:S000002989; AllianceGenome:SGD:S000002989; VEuPathDB:YGL021W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within mitotic morphogenesis checkpoint signaling. Predicted to be active in cytoplasm and nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See ALK1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (454785..457067)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pib2p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 Neighboring gene GET complex subunit GET1 Neighboring gene casein kinase 2 regulatory subunit CKB1

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity, acting on a protein IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mitotic morphogenesis checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein kinase ALK1
    NP_011494.1
    • Atypical protein kinase; along with paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; regulates the morphogenesis checkpoint in response to polarity insults through inactivation of Mih1p; phosphorylated in response to DNA damage; similar to mammalian haspins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      454785..457067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180886.1NP_011494.1  TPA: protein kinase ALK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011494.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUB6, P43633
      UniProtKB/TrEMBL
      A0A8H4C1F3, G2WE72, N1P5K8
      Conserved Domains (1) summary
      cl21453
      Location:211760
      PKc_like; Protein Kinases, catalytic domain