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    GUK1 guanylate kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852065, updated on 17-May-2024

    Summary

    Gene symbol
    GUK1
    Gene description
    guanylate kinase
    Primary source
    FungiDB:YDR454C
    Locus tag
    YDR454C
    See related
    SGD:S000002862; AllianceGenome:SGD:S000002862; VEuPathDB:YDR454C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BRA3; PUR5
    Summary
    Enables guanylate kinase activity. Involved in GDP biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See GUK1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1366264..1366827, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene endopolyphosphatase Neighboring gene thioredoxin peroxidase TSA2 Neighboring gene bifunctional K:H/Na:H antiporter NHX1 Neighboring gene E3 ubiquitin-protein ligase TOM1

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanylate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in GDP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    guanylate kinase
    NP_010742.1
    • Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1366264..1366827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180762.1NP_010742.1  TPA: guanylate kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT79, P15454
      UniProtKB/TrEMBL
      A0A6A5Q2A7, A6ZZ45, B3LFK9, B5VGY4, C7GKP6, C8Z612, G2WBI5, N1P8Y7
      Conserved Domains (1) summary
      TIGR03263
      Location:3185
      guanyl_kin; guanylate kinase