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    IFITM1 interferon induced transmembrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 8519, updated on 12-May-2019

    Summary

    Official Symbol
    IFITM1provided by HGNC
    Official Full Name
    interferon induced transmembrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:5412
    See related
    Ensembl:ENSG00000185885 MIM:604456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    9-27; CD225; IFI17; LEU13; DSPA2a
    Expression
    Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See IFITM1 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (313991..315272)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (313991..315272)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S24 pseudogene 1 Neighboring gene interferon induced transmembrane protein 2 Neighboring gene interferon induced transmembrane protein 3 Neighboring gene uncharacterized LOC105376504

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 incorporates IFITM1 into virions but this incorporation does not strictly correlate with the phenotype of IFITM inhibition of HIV-1 cell-to-cell infection PubMed
    Knockdown of IFITM1/2/3 by siRNA enhances virus transmission to target cells and the production of virions in CD4+ T cells PubMed
    HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat and PBMCs-to-Jurkat) is inhibited by IFITM1 PubMed
    HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat) is inhibited by IFITM1 and this inhibition appears to be regulated by the IFITM protein C terminus, is IFITM-species specific and virus-strain specific PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 interacts with IFITM1 PubMed
    Envelope surface glycoprotein gp160, precursor env Replacement of the Env of HIV-1 BH10 with the counterpart of HIV-1 NL4-3 enables HIV-1 BH10 to replicate in IFITM1-expressing cells, whereas inserting the Env of HIV-1 BH10 into HIV-1 NL4-3 reduces virus replication in the presence of IFITM1 PubMed
    env HIV-1 NL4-3 Env inhibits IFITM1-mediated restriction of HIV-1 replication by enhancing HIV-1 cell-to-cell transmission PubMed
    env Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 interacts with IFITM1 PubMed
    Nef nef IFITM1 significantly downregulates the expression of HIV-1 Nef by interfering with Tat/TAR-mediated expression PubMed
    Pr55(Gag) gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 Gag in virus-producing cells and co-assemble with Gag into budding particles PubMed
    gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
    gag IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
    Tat tat HIV-1 Tat upregulates the expression of interferon induced transmembrane protein 1 (IFITM1) in human primary T cells PubMed
    Vif vif IFITM1 significantly downregulates the expression of HIV-1 Vif by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
    Vpr vpr HIV-1 gp160 interacts with IFITM1 PubMed
    vpr HIV-1 Vpr upregulates the expression of IFITM1 in human monocyte-derived dendritic cells PubMed
    vpr IFITM1, 2 or 3 marginally inhibit the entry of HIV-1 NL4-3 and SIV Mac into TZM-bl by measuring the cleavage of CCF2 by BlaM-Vpr that enters the cytoplasm together with viral cores PubMed
    Vpu vpu Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission PubMed
    capsid gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 CA in velocity gradients, indicating that IFITMs are virion-associated proteins PubMed
    gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
    gag Depletion of IFITM1 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed
    gag IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    response to interferon-alpha IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to interferon-gamma IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    type I interferon signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    type I interferon signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon-induced transmembrane protein 1
    Names
    dispanin subfamily A member 2a
    interferon-induced protein 17
    interferon-inducible protein 9-27
    leu-13 antigen

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003641.4NP_003632.3  interferon-induced transmembrane protein 1

      See identical proteins and their annotated locations for NP_003632.3

      Status: VALIDATED

      Source sequence(s)
      BC000897, J04164
      Consensus CDS
      CCDS41584.1
      UniProtKB/Swiss-Prot
      P13164
      UniProtKB/TrEMBL
      A0A024R210
      Related
      ENSP00000386187.3, ENST00000408968.4
      Conserved Domains (1) summary
      pfam04505
      Location:3498
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      313991..315272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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