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    SIR2 NAD-dependent histone deacetylase SIR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851520, updated on 17-May-2024

    Summary

    Gene symbol
    SIR2
    Gene description
    NAD-dependent histone deacetylase SIR2
    Primary source
    FungiDB:YDL042C
    Locus tag
    YDL042C
    See related
    SGD:S000002200; AllianceGenome:SGD:S000002200; VEuPathDB:YDL042C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MAR1
    Summary
    Enables NAD-dependent histone deacetylase activity (H3-K14 specific) and NAD-dependent histone deacetylase activity (H4-K16 specific). Contributes to nucleosome binding activity. Involved in several processes, including establishment of protein-containing complex localization to telomere; negative regulation of macromolecule metabolic process; and regulation of DNA stability. Located in chromosome, telomeric region; heterochromatin; and nucleolus. Part of RENT complex. Used to study Alzheimer's disease; Parkinson's disease; diabetes mellitus; and prostate cancer. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See SIR2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (376757..378445, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mtf2p Neighboring gene Prp11p Neighboring gene peptide alpha-N-acetyltransferase complex A subunit NAT1 Neighboring gene pheromone-regulated protein PRM7

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD-dependent histone H3K14 deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent histone H3K9 deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent histone H4K16 deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD-dependent histone H4K16 deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of protein-containing complex localization to telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA amplification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere tethering at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RENT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NAD-dependent histone deacetylase SIR2
    NP_010242.1
    • Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication, suppressing early firing of multicopy rDNA origins; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      376757..378445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180101.1NP_010242.1  TPA: NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRV4, P06700
      UniProtKB/TrEMBL
      A0A8H8UMN9, B3LGU0, B5VFM5, C8Z4M8, N1P5V5
      Conserved Domains (2) summary
      cd01408
      Location:255517
      SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
      pfam04574
      Location:104261
      DUF592; Protein of unknown function (DUF592)